Systemic Lupus Erythematosus Clinical Analysis Of The Blood System Damage

Purpose Retrospective analysis of clinical data to explore the characteristics of the blood system damage, for timely and correct diagnosis and treatment help.Methods Uses the computer medical record management system management system to retrieve in January, 2008 --2009 year in October I courtyard admitting to be clear about the diagnosis is the SLE in hospital case, altogether 325 examples, is accompanied by the systema sanguineum impairer 190 examples. Analysis of gender, age, nationality, blood type and blood system damage occurred relations; marrow image change; blood system damage and immune markers; single drug therapy, combination therapy on the efficacy of different types of damage to the blood system; a single agent and combined treatment comparison.Results (1) The blood system damage in order to reduce the number of blood cells of two-line hair, followed by a series of simple blood cells reduced, finally, whole blood cells decreased. (2) The blood system damage in male and female rates were 80%, 69.67%, difference was not significant(P>0.05). (3) Children, middle-aged, older blood system damage rates were 71.43%, 70.43%, 70.59%, no significant difference between the three(P>0.05). (4) Of the blood system damage in Han nationality, ethnic minority rates were 70.59%, 69.81 %, There was no significant difference. (5) The blood system damage A, B, AB, O blood group rates were 76.47%, 81.63%, 91.67%, 69.64%(P>0.05). 4 had no significant difference. (6) Erythrocyte sedimentation rate is higher than normal, ANA-positive, anti-SM antibody-positive, anti-ds-DNA antibody is higher than normal, complement C3, C4 lower than normal, the blood system damage rates were 79.69%, 81.25%, 23.44 %, 69.14%, 76.17%, 58.98%, 71.48%. The Logistic regression analysis: the blood system damage increases as the ESR, C3 levels increased to reduce. (7) 33 routine marrow morphology inspection: WBC, Hb, PLT reduction respectively is 16 examples (48.48%), 27 examples (81.82%), 27 examples (81.82%); The marrow grain is, red is, the macronucleus is damping respectively is 5 examples (15.15%), 10 examples (30.3%), 11 examples (33.33%), the marrow changes and the circumference blood picture change not parallel relations (P<0.05).(8) 229 cases of patients with blood system damage in blood 2-4 weeks later there were 204 cases, corticosteroids were given conventional treatment, 97 patients were given gamma globulin and (or) immune inhibitor combination therapy, combination therapy over single- drug treatment more effective.Conclusion 1.SLE blood system damage in order to reduce the more common two-line, the lack of specificity. 2. The blood system damage incidence and sex, age, nationality, blood type has nothing to do. 3. The marrow changes and the circumference blood picture change likely not parallel, does not have the specificity. 4. Complement C3, the erythrocyte sedimentation rate may take judge the SLE condition activity and to treat the response evaluation the important target.5. Alone or in combination with glucocorticoid therapy on many types of damage to blood system effective, combination therapy more effective.6. Some glucocorticoid therapy alone ineffective blood system damage, the treatment is effective.7. SLE patients leukopenia and thrombocytopenia treatment effect is better than the therapeutic effect of anemia.