Expression Of High Mobility Group Box 1 Protein In Serum And Tissue In Endometriosis And Its Mechanisms

ObjectiveTo investigate the expression of High mobility group box 1 protein in tissues of endometriosis as well as its function and the clinical value of High mobility group box 1 protein in sera of endometriosis.MethodsThe preoperational level of serum HMGB1 was measured by enzyme-linked immunoassay in 53 cases of endometriosis. The expression of HMGB1 and RAGE in tissue of endometriosis was measured by immunohistochemical assay in 56 cases of endometriosisResults1,The preoperational level of serum HMGB1 was significantly higher (76.833±13.771ng/ml) in 53 patients with endometriosis than that of ovarian benign epithelial neoplasm (8.374±5.404ng/ml) and healthy controls (0.577±1.263 ng/ml) (P<0.01). And the level of serum HMGB1 in ovarian benign epithelial neoplasm was higher compared with healthy controls (P< 0.01).2,HMGB1 was expressed in the gland epithelium cells, the expression of HMGB1 in ectopic glandular epithelium nuclei and the cytoplasm was higher than the benign ovarian tumor,were higher than that of ovarian benign epithelial neoplasm(P<0.01).Ectopic endometrium could not change from proliferative to secretory stage.3,RAGE was expressed in the in membranes of ectopic endometrium cell and brown granules were found.The expression of RAGE in endometriosis lesion was higher than that of varian benign epithelial neoplasm(P<0.01).Conclusion1.HMGB1 and RAGE were overexpressed in ectopic endometrium,this finding suggests that HMGB1 and RAGE may be correlated with adherence and aggression in endometriosis.2. The level of serum HMGB1 may be useful in differential diagnosis of pelvic cyst...