Refreshing Dripping Pills Preparation Process And Quality Standards Research

Xingnao pilule is a compound preparation of Chinese medicine based on the experienced prescription xingnao mixtures which is an effective recipe to prevent and cure the hemorrhage apoplexy. It is prepared from the extracts of Radix notoginseng,Rhizoma chuanxiong, Rardix et Rhizoma rhei. It can invigorate the circulation of blood and stop bleeding or hemorrhage. What is more, it can develop the immunity from disease. So ,it can evidently reduce the rate of paralysis for apoplexy. The research include the preparation and quality standard by HPLC and TCL methods, which is based on the analysis of the prescription and active constituents, according to "the method of the new drugs approval" . 1. The effective constituent in every Chinese medicine is quantified, which is up to the standard of 2000 edition's Chinese pharmacopoeia. 2.The extracting technique of notoginseng is studied, which is based on the parameter of the ginsenoside transfer rate. The optimized extracting technique is boiling the crude drugs twice for one hour with eight and six times 70% ethanol.3. The extracting technique of chuanxiong is studied, which is based on the parameter of the ferulic acid transfer rate. The optimized extracting technique is boiling the crude drugs twice for two hour with eight and six times 80% ethanol.4. The extracting technique of rhei is studied, which is based on theparameter of the emodin transfer rate. The optimized extracting technique is boiling the crude drugs three times for one and a half hours with twelve times water, concentraning extraction as 1ml equate 0.8g drugs, and then adding 95% ethanol to the concentration of ethanol to 80%, dispositing for 12 hours.5. Study the technics of the pilule shape: select the PEG-6000 as pedestal, choose the optimal ratio of the extraction of crude drugs and the pedestal according to the state of the extraction dissolve and dispersion condition when the preparation were made. What's more,the speed of release is an important parameter. The bigger rate of PEG-6000,the sooner speed of the preparation release, and the bigger degree of dispersion . the optimal ratio of extraction and PEG-6000 is 1:6.6. we research the quality control method of the xingnao pilule formulation and draw up the claim of crude drugs and the quality standards of preparation. We set up the quality control method of ginsenoside- Rg1,Rb1 content by HPLC. Chuanxiong and Rhei were identified by TLC.