Particles Of Anti-rheumatic Preparation Process And Quality Standards

Compound Anti-rheumatoid arthritis granule is made of Radix aconite ,Radix astragalus membranaceus,Radix paeoniae alba,Caulis ephedrae,Radix glycyrrhizae ,The prescription of Anti-rheumatoid arthritis granule was a effective recipe that has been written in 《Synopisis of the Golden chamber》by doctor Zhang zhongjing. The efficiencies of Anti-rheumatoid arthritis granule are cleaning away prolonged cold-damp obstruction , expelling cold and damp pathogen , warming meridian to activate , subduing swelling and alleviating pain , which is used to treat rheumatoid arthritis. With the guide of Chinese medicine theory , conduct the analyses on the medicine of the prescription , establish the distill method and conduct procedure pick up depending on the component of Chinese medicine. 1.Reseracher on preparation procedure: To make the Radix aconite comparing the reflux method to is two kinds of to withdraw the method with the method of seepage, combine to investigate the method of seepage withdraw the term, investigating the medicine material smash granularity(6,8,12item), solvent dosage(24,32,40 times), sour density(0.1%,0.3%,0.5%), with a total alkali with an ester type alkaloid is synthesizes to investigate the contents, make sure to withdraw the means best. Radix astragalus membranaceus contents astragaloside , flavones ,astralanI,pharmacologic test shows that astraloside is efficacy to lenitive component , establish the best distill procedure with the content of astragaloside IV as the component index , select the best solvent (distilled water , distilled water-alcohol 50% deposition , alcohol 50%, alcohol 70%) ,and alcohol adding quantity (18times,22imest,26times) , and distill time (2hour,3hour,4hour) , and distill step (1,2,3step). pharmacologic test shows that of Radix paeoniae alba can mitigation and alleviating pain , with HPLC method measurement content of paeoniflorin , compare distill circumfluence and supersound , review the consistency of alcohol ( water,30%,50% ,70%). Then with fit menstruum proceed craft optimization, review distill time(1,2,3 times), menstruum dosage(14,18,22 timeses), distill number of times(1,2,3) , choose the best condition. Main composition in Caulis ephedrae alkaloid, naphtha, among them the alkaloid composition contains the deal very high, the main clinical medicine reason research expresses its have the alleviating pain function, the alkaloid in Caulis ephedrae distill the craft for the index sign optimization. Select menstruum (distilled water , distilled water-alcohol 50% deposition , alcohol 50%, alcohol 70%),and alcohol adding quantity (14times,18imest,22times) , and distill time (1hour,1.5hour,2hour) , distill number of times(1,2,3times)。 The main composition in licorice is sweet element and flavonoid compositions, therefore using efficiently liquid mutually the method measurement licorice is element to contain the deal makes sure to distill the term.Review pick-up menstruum (alcohol of 70%,50%,30% of contain ammonia 0.3%),distill time(2,1.5,1.5;1.5,1,1;1,05,05),menstruum dosage(16,22,28times) Research on the shaping procedure: Review the soft material kind, the granule of system is difficult easy, grain color and agglomeration for index, investigate the powder of medicine and the comparison of the dextrine , the smooth wet certain grain in a density(80%,85%,90%) of ether models the term. 2.Quantity standard research The characteristic compositions were taken as the the indexs with TLC to identify the quality of prepared Radix aconite ,Radix astragalus membranaceus,Radix paeoniae alba,Caulis ephedrae,Radix glycyrrhizae.The content of aconitine and astragaloside IV in the granule was determined with reviewing absorbency and folium scan.