Studies On The Cyclization Of The Zwitterionic And Alkyne Benzaldehyde Oxime

The zwitterion chemistry is become one of the most important parts in synthetic chemistry. And how to generated them in situ occupied most proportion in recent years. Recently, aryne chemistry is arised more and more attentions because o-silyl aryltriflates could be easily prepared, and be generated in situ. We summarized these reports include the azide and azomethine dipolars cycloadditions in the chapter one.Within the chapter two, a gold catalyzed dipolar reaction were developed under mild conditions.2-alkynylbenzaldoxime was demonstrated as a versatile building block for the synthesis of N-heterocycles. And at the last, we established a green, solvent and catalyst free process to produced isoquinoline-N-oxide in a high yield (99%) using the2-alkynylbenzaldoxime as the starting material. All the reactions were carried out under mild conditions. The structures of products further confirmed by1H NMR,13C NMR and Mass spectras.