Effects Of Till - Like Receptor 4 On Overexpression Of Small Intestine In Patients With Primary Liver Cancer And Its Relationship With Toll - Like Receptor

Objective: To discuss the condition of small intestinal bacterial overgrowth(SIBO) in patients with primary liver cancer and the roles of intestinal flora and toll-like receptor 4(TLR4) played in the occurrence and development of primary liver cancer.Methods: 51 patients with primary liver cancer and 20 healthy controls were all detected by glucose hydrogen breath test(GHBT) to detect the condition of SIBO and then compared the difference of SIBO positive incidence in both groups; In addition, the immunohistochemical method was used to detect the expression of TLR4 protein on human hepatocellular carcinoma tissue of all subjects.Results: Of 51 patients with primary liver cancer, 37(72.6%) were SIBO positive and14(27.4%) were GHBT negative, while in the control group, no one was GHBT positive. The difference in the incidence of SIBO between liver cancer patients and control group was statistically significant(χ2 = 30.3, P = 0.000). The expressions of TLR4 were different in all liver cancer tissues, and in normal liver tissue it had only a small amount of expression. In patients with liver cancer, the expression level of TLR4 in SIBO positive patients was higher than that of SIBO negative(χ2 = 5.088, P =.024).Conclusion: Patients with primary liver cancer are prone to SIBO, and the intestinal flora may promote the occurrence of liver cancer through the expression of TLR4.