A Cross - Sectional Study Of Fatigue And Related Factors In Patients With Primary Sjogren 's Syndrome

Purpose:To investigate the prevalence and the relationships of fatigue in patients with primary Sjogren’s Syndrome, which is prepared for intervention in clinical.Material and method:We identified 95 subjects who met the American-European consensus criteria for the classification of PSS. Fatigue was assessed with a Visual Analogue Scale(VAS), the Fatigue Severity Scale(FSS) and the Profile of Fatigue(Pro F). Association of fatigue was compared using Logistic regression and Correlation Coefficient Analysis.Results: 1. p SS-related fatigue defined as a FSS score of greater than or equal to 4 was present in 44.2% of the patients. Fatigued patients had higher score of CES-D, CRP, C3 and Ig G than not fatigue(P<0.05). 2. There were on relationship between p SS-related fatigue and gender, ages, location, level of education(P>0.05). The Logistic regression models explained p SS-related fatigue was related with Ig G(OR 1.419 [95%CI 1.108-1.817]), depressives OR(1.162[95%CI 1.047-1.290]) and courses of disease(OR 1.019[95%CI 1.004-1.034]). 3. According to Correlation Coefficient Analysis, the level of fatigue is associated with depression, Ig M Ig A and Ig G(P<0.05). According to the results of multiple liner regression, the contributions of variables to level of fatigue respective FSS(22.5%), VAS(17.0%), Pro F-S(48.7%), Pro F-M(21.5 %).Conclusion: Patients were with higher levels of Ig G, depression or the longer course of disease more likely to be present of fatigue. Depression is more likely to be one of predictors of level of fatigue. For the limitation of cross-section study, investigation of the pathophysiologic correlates of physical and mental aspects of fatigue is needed to guide the development of more effective interventions.