Syndromes Of Syndromes In 194 Patients With Chronic Hepatitis C And Experience Of Syndrome Differentiation And Treatment

Purpose:This study through the retrospective survey of patients with chronic hepatitis c(CHC), summarize the distribution of Traditional Chinese Medicine syndrome type, discusse the relationship between Traditional Chinese Medicine syndrome types and the correlation of the physicochemical indexes of the types, and summarize professor Lu Bingjiu’s clinical experience in the therapy of the disease, to provide reference for clinical diagnosis and treatment of CHC.Material and method:From July 2014 to August 2015, 194 cases of patients with chronic hepatitis C were collected from the infectious disease clinic of Liaoning University of Traditional Chinese Medicine. Collect the clinical data, including medical history, symptoms, tongue and pulse, physical and chemical examination, etc. Establish database and use the SPSS22.0 statistical software to analyze the data. Research the relationship between CHC Traditional Chinese Medicine syndrome distribution and syndrome type of traditional Chinese medicine research and the physicochemical index. According to the results of the study and combining with Professor Lu’s experience in the diagnosis and treatment of the disease, this paper briefly describes the significance of this study for the clinical treatment.Results: 1.194 cases of CHC patients are in the majority of middle-aged, the majority of patients with infection is not clear, but the blood transfusion remains the high-risk infection, most patients have a history of interferon therapy. 2.The main symptoms of the patients is with anorexia, irritability, yellow urination, fatigue. Most color of the tongue are red and pale.The main pulse condition are sink, string and small. 3.The main clinical manifestations of 194 cases of CHC patients can be classified into four syndrome elements: liver depression, damp heat, insufficiency of the spleen and deficiency of yin. 4.194 cases of CHC patients divided into 6 kinds of syndrome type: dampness-heat of liver and gallbladder, stagnation of liver qi and spleen deficiency, yin deficiency of liver and kidney, yang deficiency of spleen and kidney, lingering pathogen due to deficient vital qi and static blood blocking collaterals, the most common type is dampness-heat of liver and gallbladder. 5.The patients of dampness-heat of liver and gallbladder are the youngest and having the shortest course of disease; the patients of yang deficiency of spleen and kidney are the oldest and having the longest course of disease; most of the patients of dampness-heat of liver and gallbladder have drinking history; and most of the patients of yin deficiency of liver and kidney have interferon treatment history. 6.In the aspect of physical examination: The mean value of ALT、AST、AST/ALT、TBIL and DBIL are highest during the patients of dampness-heat of liver and gallbladder; TBIL and DBIL of the patients of dampness-heat of liver and gallbladder and yin deficiency of liver and kidney have statistically significant difference with other types(P<0.01,P<0.05);The level of HCV-RNA during the types has no statistically significant difference(P>0.05). 7.B ultrasound:The static blood blocking collaterals has the hightest value in the width of portal vein and the thickness of spleen; the dampness-heat of liver and gallbladder has the lowest value. 8.Professor Lu in clinical diagnosis and treatment process pays attention to the regulating the liver and maintining of the spleen, righting evil spirits and to clear heat and expel damp. Conclusion: 1.CHC patients with clinical symptoms are different, the cluster analysis can be classified as liver depression, damp heat, insufficiency of the spleen and deficiency of yin four syndrome elements; the syndrome differentiation can be divided into dampness-heat of liver and gallbladder, stagnation of liver qi and spleen deficiency, yin deficiency of liver and kidney, yang deficiency of spleen and kidney, lingering pathogen due to deficient vital qi and static blood blocking collaterals, 6 kinds of syndrome type,the most common type is dampness-heat of liver and gallbladder. 2.The differences of physical and chemical indexes between different types of CHC patients were different: the dampness-heat of liver and gallbladder more performance as high value of TBIL and DBIL;The static blood blocking collaterals is heavy in the width of portal vein and the thickness of spleen.3.Professor Lu uses regulating the liver and maintining of the spleen, righting evil spirits and to clear heat and expel damp as method, combining traditional Chinese medicine and Western medicine treatment can effectively improve the clinical symptoms of CHC patients.