Study On The Related Factors Of Diabetic Retinopathy And The TCM Syndrome Factors

Objective:On patients with DR gender, age, BMI, course of diseases, FPG, the correlation between HbAlc and DR;Analysis of DM patients with disease and correlation;DR TCM syndrome elements and DR various classification, the relationship between the DME;For prevention, early detection and treatment of DR lesion and provide clinical help slow DR progress.Methods:In January 2015 to December 2015 in Beijing university of Chinese medicine during the first clinical medical college of ophthalmology consultation all our patients take retrospective investigation, choose the first clinical hospital diagnosed with diabetes.Patient information collection, statistics of the patient’s gender, age, BMI, course of diseases, Fasting glucose, (Fasting Plasma glucose, FPG), Glycosylated hemoglobin (Glycosylated hemoglobin Alc, HbAlc), merger disease and TCM four diagnostic data, ophthalmology consultation, etc.412 patients with DM were carried out in accordance with the 2002 DR international clinical classification standard group, divided into 5 groups and 2 large groups, namely:5 of 5 groups respectively, among them,2 big respectively NDR group (not seen obvious diabetic retinopathy, level 1).DR group (diabetic retinopathy,2,3,4,5).By using SPSS17.0 statistical software for statistical analysis, between gender and incidence of DR adopts four table chi-square test;Age, duration of DM, FPG, HbAlc are to classify two Logistic regression analysis, and the duration of DM, FPG, chi-square HbAlc;And;In addition, diabetic nephropathy, diabetic peripheral neuropathy and diabetic foot disease, hypertension, hyperlipidemia, high uric acid fact, coronary heart disease, cerebrovascular disease and DR binary classification Logistic regression analysis.Using chi-square analysis DR TCM syndrome elements and the relationship between the 5 groups of DR DME.Results:1. Statistical inspection, respectively, between gender and incidence of DR results:gender and NDR, DR between four table chi-square test, there was no statistically significant difference between the groups (P>0.05), and that gender has nothing to do with DR incidence;2 patients’age,BMI, course of diseases, FPG, HbAlc Logistic regression analysis, Logistic regression equations, age and BMI factors of P values<0.05;And of course, FPG, HbAlc OR values are:0.909,1.129,0.563, and P values were 0.000< 0.01, the regression equation is highly statistically significant.DM course, FPG, HbAlc is DR occur significant risk factors, and age and BMI is not a risk factor for DR occurred.3 For patients with DM course, FPG, HbAlc respectively between DR and chi-square test, concluded that the difference was statistically significant between DM course and DR, think DM course of more than 10 years DR prevalence increased obviously;FPG and DR between difference had statistical significance (P>0.05), once the FPG may not be a risk factor for DR, but there was no statistically significant difference between HbAlc and DR (P<0.05), HbAlc>8 groups had DR rate is higher, the higher HbAlc, susceptible to DR.4. In this paper, DN and diabetic peripheral neuropathy, diabetic foot, hypertension, hyperlipidemia, high uric acid hematic disease, coronary heart disease, cerebrovascular disease frequency, frequency of these diseases in DR group were higher than in NDR group.In addition, the patients of DN, diabetes peripheral neuropathy, diabetic foot, hypertension, hyperlipidemia, high uric acid hematic disease, coronary heart disease, cerebrovascular disease as independent variables, the Logistic regression analysis, draw the conclusion:DN, hypertension is a risk factor for DR, diabetic peripheral neuropathy and diabetic foot, hyperlipidemia, high uric acid hematic disease, coronary heart disease, cerebrovascular disease, there is no direct correlation with DR.5. The high frequency of 10 syndrome elements are compared, and 5 groups of DR between qi deficiency syndrome, blood stasis, hot and dry syndrome, qi depression and spleen deficiency syndrome in DR differences between 5 group were no statistical significance (P> 0.05);Namely:qi deficiency syndrome, blood stasis, hot and dry syndrome, qi depression and spleen deficiency syndrome in 5 groups between DR distribution are the same;And liver deficiency syndrome, Yin deficiency syndrome and Yang deficiency syndrome, phlegm dampness syndromes, kidney deficiency among 5 groups DR difference had statistical significance (P<0.05);Namely:liver deficiency syndrome, Yin deficiency syndrome and Yang deficiency syndrome, phlegm dampness syndromes, kidney deficiency in group 5 DR distribution between different:(1) liver deficiency syndrome in less than 2,3,4,5, the other has no obvious difference between two levels, namely:NDR liver deficiency is less than the DR group;(2) often appear at level 1,2,3,4,5 levels appear the most, as DR is aggravating, Yin deficiency syndrome is also on the rise;(3) actions in grade 1,2,3, less, gradually increase in the level 4,5, as DR illness aggravating, the late DR Yang deficiency symptoms significantly increased;(4) phlegm dampness syndromes and kidney deficiency in grade 1 is less, in 2, level 3 is higher, in the highest at level 4,5, as DR illness aggravating, phlegm dampness syndromes and kidney deficiency also will increase6. The composite syndrome elements found that 2 syndrome appear more as:qi deficiency +heat syndrome, deficiency syndrome, blood stasis syndrome, qi deficiency and liver deficiency syndrome;Type 3 card appear more as:qi deficiency syndrome+hot++heat syndrome, qi deficiency syndrome of blood stasis syndrome, liver deficiency, qi deficiency syndrome and liver deficiency syndrome and blood stasis.7. Qi deficiency syndrome, Yin deficiency, spleen deficiency, liver deficiency syndrome, blood stasis and heat syndrome and phlegm fever have no correlation with the incidence of DME;And Yang deficiency syndrome and phlegm dampness syndrome is associated with the incidence of DME, and DME occurs mainly in the middle-late DR, closely associated with Yang deficiency and phlegm dampness syndrome.Conclusions:DR is a variety of factors influence each other and produce disease, in which the DM duration, FPG, HbAlc, diabetes, kidney disease, high blood pressure is a significant risk factor, DR happened and DM course of more than 10 years, HbAlc>8 DR prevalence increased obviously;Frequency combination of syndrome elements that DR, qi deficiency syndrome, heat syndrome, blood stasis, liver deficiency syndrome, Yin deficiency syndrome appear more, and liver deficiency syndrome DR group obviously higher than that of NDR group, Yin deficiency syndrome in the late heavier, qi deficiency syndrome associated with the disease process;Qi depression syndrome and Yang deficiency syndrome, spleen deficiency syndrome and phlegm damp syndrome, kidney syndrome appear slightly less, but late wet card and card of kidney Yang deficiency syndrome, phlegm significantly increased;Qi deficiency in composite type 2,3 card to card+heat syndrome, deficiency of most+heat syndrome, blood stasis;And DME occurs mainly in the middle-late DR, closely associated with Yang deficiency syndrome and phlegm dampness syndrome.