Expression Of C-Met And CXCR4 In Colorectal Cancer And The Relationship With Liver Metastasis

Objective: To explore the expression of c-Met and CXCR4 in surrounding normal colorectal tissue, colorectal adenoma, colorectal cancer, and the relationship with development and liver metastasis of colorectal cancer, to predict the occurrence of liver metastasis of colorectal cancer provides a theoretical foundation, while trying to look for possible targeted therapy for therapeutic targets.Methods: The expression of c-Met and CXCR4 was detected by EliVisionTM plus immunohistochemical method in 15 surrounding normal colorectal tissue,15 colorectal adenoma, 48 colorectal cancer. The correlation of c-Met and CXCR4 and their relationship of clinicopathologic characteristics including liver metastasis, lymphatic metastasis, dukes staging, age, sex, location and differentiation was demonstrated.Result: The expression rate of c-Met in surrounding normal colorectal tissue,colorectal adenoma and colorectal cancer was 20.0%,40.0% and 70.8%. The expression rate of CXCR4 in surrounding normal colorectal tissue,colorectal adenoma and colorectal cancer was 0.0%,13.3% and 43.3%. The expression of c-Met and CXCR4 in surrounding normal colorectal tissue and colorectal adenoma was significantly lower than that in colorectal cancer. There was no difference between surrounding normal colorectal tissue and colorectal adenoma. The expression of c-Met and CXCR4 in colorectal cancer with liver metastasis was significantly higher than that with no liver metastasis, and was relevant with lymphatic metastasis and dukes staging but irrelevant with age, sex, location and differentiation. The expression of c-Met in colorectal cancer was correlative with that of CXCR4. Conclusion: The expression of c-Met and CXCR4 in colorectal cancer is correlative and associated with carcinogenesis, development and liver metastasis in colorectal cancer.