Gu Jin Xiao Liu Jiao Nang On The Efficiency Of Chemotherapy Tumor-bearing Mice Attenuated Experimental Study

Objective: Solid Gold eliminate tumor capsule on tumor-bearing mice attenuated the synergistic effect of chemotherapy experiments, observations of their in vivo tumor vascular endothelial growth factor in the distribution of impacts, and solid tumors in mice of the anti-tumor effect and help enhance the implementation of the chemotherapy The role of immunity in mice.Method:1, efficiency experiment:the C57BL/6 inbred mice were Randomly divided into six groups, tumor-bearing mice inoculated with lewis dilution of tumor cell,mice cells,mice Were killed 15 days later ,take tumor weighing,save tumor immunohistochemical staining of vascular endothelial growth factor measurement.2,attenuated experiment: the C57BL/6 inbred mice were randomly divided into six groups, a daily gavage once, injecting drug use cyclophosphamide, 15 days later, after the ball to take blood and femur collected to carry out calculation of white blood cell count and bone marrow cell counts.Results: 1, efficiency testing of low-dose of cyclophosphamide increased doses of solid gold consumption in the tumor capsule can significantly inhibit tumor of vascular endothelial growth factor in vivo distribution, increasing the inhibitory rate of low-dose cyclophosphamide. 2, attenuated experimental high-dose cyclophosphamide increased the dose of solid gold consumer tumor capsule can significantly reduce the large doses of toxic side effects circulation amide enhance peripheral tumor-bearing mice in the number of white blood cells and bone marrow cells.Conclusion: The solid gold consumption can increase tumor capsule dose cyclophosphamide inhibition of tumor block the role of vascular endothelial growth factor levels and the role of inhibition of tumor volume. Solid gold consumption can reduce the tumor capsule dose cyclophosphamide on inhibition of blood cell and bone marrow as the inhibition.