| Purpose:Rheumatoid arthritis (Rheumatoid arthritis, RA) is a chronic inflammatory, systemic autoimmune diseases, extremely broad distribution, with symmetry, sexual, and destructive joint disease as the main features of peripheral joints showed sustained and progressive synovitis in turn cause cartilage destruction and bone erosion, resulting in joint deformities, resulting in varying degrees of disability. Morbidity is high, the more serious threat to people's health. Modern medicine, the cause of rheumatoid arthritis is not clear, and the incidence of infection-related factors, genetic factors, cytokines factors and endocrine factors. In the treatment, no specific treatment methods, clinical treatment of part of western medicine proved effective, but prone to a variety of adverse reactions in patients with difficult to uphold a long history of Chinese medicine treatment of RA, a large number of clinical studies have shown that Chinese medicine treatment of RA with anti-inflammatory analgesic, immune suppression, immune regulation triple effect, and most of the traditional Chinese medicine has few side effects, easy to insist on taking the characteristics of clinical application and therefore has many advantages. In recent years, many Chinese physicians of traditional Chinese medicine on the basis of knowledge of Bi Syndrome, learn contemporary advanced technological means to continuously enrich the content of Bi Syndrome, using micro-qualitative and quantitative research methods to explore indicators of rheumatoid arthritis and immune, cytokines such as changes in correlation to study the mechanism of Chinese medicine, has made some breakthroughs.Proposed by this research, and laboratory parameters of rheumatoid arthritis and hemorheology indexes related to the phenomenon and analyze the effects of western medicine, the western medicine treatment programs optimized to provide a basis to identify effective clinical characteristics of patients with data, in accordance with relevant clinical symptoms, improve clinical efficacy of targeting the development of scientific programs. To investigate the mechanism of Chinese medicine and treatment of new ways to do some groundwork for the clinical treatment of early intervention to provide new ideas, and to provide the scientific basis for evaluation of treatment.Method:(1) control group:leflunomide tablets (trade name:Arava, 10mg/film, Suzhou Changzheng-Xin Kai Pharmaceutical Co., Ltd. production, batch number:H20000550) 20mg/day orally for 1 day. Meloxicam tablet (Yangtze River Pharmaceutical Group Co., Ltd. Production) 7.5mg/times,2 times/day, meal service. (2) treatment groups:control group, medication, based on traditional Chinese medicine blood stasis mixture was added decoction per 200ml, twice a day, oral. Course of treatment:3 months of a course of treatment, observation of a course of treatment. Before and after treatment and weekly to conduct a comprehensive physical examination of the observed cases of a second to observe the degree of joint pain, morning stiffness time, swelling index, the average grip strength, HAQ index, and laboratory indicators such as blood rheology, ESR, RF, CRP, etc. treatment before and after a time of the inspection, are in the observation after the conclusion of efficacy evaluation.Results:1 comparison of total effective:After treatment, patients with significantly reduced clinical symptoms and signs, laboratory parameters improved significantly. Among them, the treatment group, the total effective rate was 87.5%, significantly higher (P<0.05).2 Comparison of clinical symptoms and signs:blood circulation mixture of Chinese medicine combined leflunomide tablets, dispersible tablets of meloxicam significant improvement in rheumatoid arthritis patients with clinical symptoms and signs, including joint pain index, swelling index, HAQ index, dysfunction index was significantly decreased time of morning stiffness was significantly shorter with both hands an average grip strength increased significantly compared with the control group the degree of improvement is more obvious.3 Laboratory of indicators improved:the abnormal laboratory indicators improved significantly, ESR, RF, CRP, IgA, IgG, complement C3 indicators, hemorheology index ESR, whole blood viscosity, plasma viscosity, hematocrit, platelet adhesion rate and erythrocyte electrophoresis, compared with the control group the degree of improvement is more obvious.4 Security:treatment group,4 patients after 4 weeks of medication, nausea,3 patients suffer from abdominal pain after 2 weeks of medication, the absence of special treatment, symptoms disappeared after treatment, no obvious damage to liver and kidney function, and other adverse reactions.Conclusion:Mixture of Chinese medicine blood stasis combined lef lunomide tablets, meloxicam tablet in patients with rheumatoid arthritis, joint pain, joint swelling, joint tenderness symptoms were significantly improved, can significantly improve the double-grip strength, improve dysfunction, reduced ESR, RF, CRP, IgA, IgG, complement C3 indicators, hemorheology index ESR, whole blood viscosity, plasma viscosity, hematocrit, platelet adhesion rate and erythrocyte electrophoresis. Among them, joint pain index, time of morning stiffness, ESR, whole blood viscosity, plasma viscosity, hematocrit, platelet adhesion rate and erythrocyte electrophoresis indicators, the treatment group improved more significantly than the control group. Studies have shown that blood circulation above mixture of Chinese medicine combined leflunomide tablets, meloxicam tablet rheology of rheumatoid arthritis with a positive therapeutic effect, and the oral use of safe, stable quality, it is worth strong clinical popularization and application, with a view to the patient. |
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