Esophageal Cancer, Lung Cancer, Preoperative Plasma D-dimer Levels After The Study

Objective:Esophageal cancer, lung cancer incidence and mortality rates are among the forefront of cancer patients, their treatment is mainly: surgery, radiotherapy, chemotherapy, surgery is still an opportunity for patients with surgical resection is still the preferred treatment [1]. Cancer patient's own coagulation and fibrinolysis abnormalities, plasma D-dimer levels increased, while the esophageal cancer, lung cancer resection wounds big, big risk of postoperative pulmonary embolism after operation may also be caused by plasma D-dimer the levels of increase. Identification of esophageal cancer, lung cancer, after surgical removal of the change of plasma D-dimer in the law, for determining esophageal cancer, lung cancer, treatment and prognosis,especially for the diagnosis of pulmonary embolism after a very important significance.Method:1 Select the January 1, 2009 to December 31, 2009 Thoracic Surgery, Hebei Medical University 4th Hospital, hospital ward there were two opportunities for esophageal cancer surgery, patients with lung cancer.2 Respectively, prior to surgery and after 1,5,9 days, collected blood, the use of colloidal gold each time determination of D-dimer levels.3 Through the D-dimer values change, to identify D-dimer in the changes of peri-operative period, as well as analyze the D-dimer correlated with age, gender, surgical methods, different diseases, pathological staging , as well as pulmonary embolism has occurred, whether the relationship between the application of anticoagulant drugs. (anticoagulant drug use: the choice of the older than past history or hypertension, the operation of the victims trauma was after two or three days without the active blood, the application for the liver of a low sodium ingection 5000 u ,inject through around navel,qd)4 Experimental data using SPSS13.0 software for statistical analysis. D-dimer of the data with the mean±standard deviation expressed as a method of using repeated measurements analysis, P <0.05 for the difference was significant.Results:1 From a different perspective to analyze the gender with the preoperative and postoperative D-dimer in the relationship between the content changes, statistical analysis showed that: different gender and different time periods before and after surgery there is no interaction between the different time pairs of D-dimer change significantly, gender differences in pairs of D-dimer were no significant changes.2 Will in all patients by age (in 60 years as the cutoff point) in a different classification of patients of different age, before and after surgery at each time point the changes in D-dimer results show that: different ages and different time between pairs of D-dimer content of no interaction between different pairs of D-dimer in the time spent by the continuing impact of the changes and age differences between pairs of D-dimer in the impact of changes also have significant differences.3 According to different kinds of disease (squamous cell carcinoma, adenocarcinoma) classification, study patients before and after D-dimer levels, through statistical analysis, research obtained: different diseases with different kinds of time on D-dimer content did not affect the interaction between the different time to affect the changes in D-dimer, namely, the various time points before and after operation D-dimer levels significantly change most of the rise, you can show that surgery on the D-dimer in older diseases, differences between pairs of D-dimer was no significant difference in change.4 By different surgical approach (esophagectomy, esophageal aortic arch, the arch anastomosis, as well as lung cancer, lobectomy) and point of view, emerging from the study patients at each time point before and after D-dimer changes: different surgical procedures no interaction between method and time, different time on D-dimer changes affect surgical differences on D-dimer were no significant changes.5 With the different pathological types (squamous cell carcinoma, adenocarcinoma) to study patients before and after 1,5,9 days of D-dimer levels, through statistical analysis, the outcome is as follows: the different pathological types and different time there is no interaction between the different time to affect the changes in D-dimer, namely, D-dimer before and after surgery the changes are fairly obvious, differences between pathological types of changes on the D-dimer is not significant.6 By studying the different clinical stages (T3N0M0, T3N1M0, T4N0M0, T4N1M0) at each time point before and after surgery, D-dimer content in the means with statistical analysis, the results described as follows: different clinical stages with different time there is no interaction between the different time to affect the changes in D-dimer, namely, D-dimer levels before and after operation was significant, and different clinical stages of the changes in D-dimer levels may affect the No significant difference.7 Have been applied before and after surgery in patients with heparin as well as an impact of D-dimer levels, the prevention of postoperative thrombosis, an important factor in fatal complications, through its research, statistical analysis obtained the following results: Is heparin and there is no interaction between the different time, different time on D-dimer changes affect the application of heparin difference of D-dimer changes are significant, but the significant difference, and clinical expectations Contrary to the conclusion , the application of heparin patient groups higher than those without application of group D-dimer levels of reason and research methods of the different.Later, the study can be used as D-dimer reference point.Conclusion:1 Through D-dimer in a different gender, age, diseases, surgical and pathological types,Clinical stage, whether heparin and other factors all affect the research and analysis, obtained: different age, and whether heparin and different time points before and after surgery for esophageal cancer, lung cancer surgery patients before and after D-dimer levels change impact, and different gender, diseases, surgical, pathological type and clinical staging of esophageal cancer, lung cancer surgery in patients with D-dimer levels before and after the change there was no significant difference.2 Different time points before and after surgery esophageal cancer, lung cancer, plasma D-dimer levels of the variableOf the more significant post-operative D-dimer were significantly higher, that is, the trauma of surgeryThe effects of D-dimer is significant, so esophageal cancer, lung cancer, surgery can be used.D-dimer levels of monitoring, to the timely application of anticoagulant drugs to prevent pulmonary embolism and other thrombotic Sexual diseases.3 Through the study of D-dimer can guide the clinical, surgical patients and in particular a number of years.Age the greater preoperative preparation, postoperative recovery have important guiding significance, while esophageal.Cancer, lung cancer study of D-dimer levels can also be observed before surgery in which both.The coagulation status of surgical risk assessment has some significance.