| Objective To investigate the association of oxidized low density lipoprotein antibo-dy(ox-LDLAb) with coronary artery disease (CAD) and Gensini score in 138 patients undergoing quantitative coronary angiography for suspected CAD, and also to find the relationship of C-reactive protein (CRP) and interleukin-6 (IL-6) with coronary artery disease and Gensini score.Methods 138 patients undergoing quantitative coronary angiography for suspected CAD were involved in this study. we measured the titer of ox-LDLAb, CRP and IL-6. And also we recorded their clinical feature:gender, age, history of hypertension, diabetes and smoking, body mass index (BMI), and the titer of serum cholesterol and glucose. Angiography and Gensini score were performed and evaluated by experienced cardiologists who were blinded to the patient's ox-LDLAb titer. The patients were categorized into control group and CAD group according to the results of Angiography. CAD group were grouped to stable angina pectoris (SAP) group and unstable angina pectoris (UAP) group according to clinical manifestation. The CAD patients were also classified to1,2 and 3-vessel-lesion group by the number of significantly stenosed (≥50%) major coronary arteries.Result The CAD group had lower titers of ox-LDLAb than control group (21.63±9.75 vs 30.37±17.3, P<0.01). And the titers of ox-LDLAb were lower in SAP group (21.53±11.18 vs 30.37±17.3, P＜0.05) and UAP group (21.69±8.89vs 30.37±17.3, P<0.05) than that in control group (P<0.05). But no differences regarding ox-LDLAb were found between SAP group and UAP group.The 2 and 3-branch-lesion group had lower titers of ox-LDLAb than 1 branch-lesion group and control group, but there were no differences between 2 and 3-branch-lesion group.The CAD group had higher titers of CRP than in control group (2.42±2.96 vs 1.26±1.32, P<0.01).And the titers of CRP was increasing stepwise in control group, SAP group and UAP group (1.26±1.32 vs 1.86±1.53 vs 2.74±1.74, P<0.01). There were no were no differences in 1,2.3-branch-lesion group, though the titer of all this three groups were higher than control group.The CAD group had higher titers of IL-6 than in control group (10.35±2.82 vs 9.10±2.30, P<0.05). The titers of IL-6 was higher in UAP group than SAP group and control group. The 3-branch-lesion group had the highest level of IL-6 in contrast to 1-branch-lesion group and 2-branch-lesion group.We found significant negative correlations between ox-LDLAb and triglyceride (TG) (r=-0.207, P=0.011), and positive correlations with high density lipoprotein cholesterol (HDL) (r=0.263, P=0.004). Morever, BMI, fasting plasma glucose, insulin also had negative correlations with ox-LDLAb, and total bilirubin, conjugated bilirubin, total protein, globulose had correlations with ox-LDLAb. But we found no correlations between ox-LDLAb and CRP or IL-6.In the correlation analyses, Gensini were significantly associated with IL-6, CRP, age, LDL, BMI, but ox-LDLAb and HDL were negatively associated with Gensini. In Linear Regression analysis of Gensini score, age, LDL, BMI, were found to be independent risk factors, and ox-LDLAb, HDL, TB were independent protective factors. But CRP, IL-6 were not independent risk factors of Gensini score.In muiltvariate analysis, taking all the factors that could affect CAD, ox-LDLAb (OR=0.270,95%CI:0.081-0.903, P=0.034), HDL (OR=0.422,95%CI:0.081-0.903, P=0.032) were demonstrated to be protective, however, CRP (OR=1.648,95%CI: 0.064-2.763, P=0.046) and IL-6 (OR=1.264,95%CI:1.033-1.540, P=0.022) were demonstrated to be independent risk factors.Conclusion The titers of ox-LDLAb were lower in angiographically assessed CAD. and ox-LDLAb was demonstrated to be protective factor of CAD.moreover there were negative correlation between ox-LDLAb and Gensini.Circulating ox-LDLAb could be associated with a protective role in atherosclerosis.CRP and IL-6 participate in development of atherosclerotic, and they have correlation with CAD and are demonstrated to be significant predictors of CAD. But, nither CRP nor IL-6 were correlated with severity of CAD assessed by coronary angiography. |
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