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Survival Analysis In Patients With Pulmonary Tuberculosis

Posted on:2011-01-25Degree:MasterType:Thesis
Country:ChinaCandidate:Q Y WuFull Text:PDF
GTID:2154360308484647Subject:Respiratory disease
Abstract/Summary:PDF Full Text Request
Objective: Tuberculosis treatment is a long-term treatment, so when the patients concerned about the cure rate of tuberculosis, they took more urgent attention in the time and probability of improving the course of treatment, This article described the dynamics of the situation and its impact factors with survival analysis in the early treatment of tuberculosis. Investigate the improvement of tuberculosis patients time, probability and impact factors.Methods: The method of survival analysis was shown to be suitable for the dynamic description of the cure effect of chronic infectious disease such as tuberculosis and for the influential factors analysis.The improved standard ,as the result event ,was the sputum negative and the chest lesions began to absorb and stability. And analysis of the survival of "life, death" as a broad concept, corresponding to the disease " improved, not improved ". Then take in our hospital from February 2009 to October 2009 to during the anti-tuberculosis drug therapy 146 pulmonary TB patients demographic information (including age, gender, diploma, smoking history), disease status (including sputum tuberculosis bacteria levels, complications, blood neutrophil percentage), treatment status (including time of starting treatment, improvement time, anti-TB treatment history, length of anti-tuberculosis programs, liver function damage) to investigate, then, applied Kaplan-meier product limit method to calculate improvement rate, univariate analysis between groups using Log-rank test, multivariate analysis using Cox proportional hazard model.Results: Survival curve shows the cumulative improvemen rates at different time points, with the continuous treatment time, the cumulative improvement rate of tuberculosis patients from low to high, close to 100% of the final, 1-month improvement rates was 26.0%, 2-month improvement cure rate was 41.8%, 3 months, the cumulative improvement rate was 63.5%, 4-month cumulative improvement rate was 73.5%, 5-month cumulative improvement rate was 79.6%, 6-month cumulative improvement rate was 89.0%, 7-month cumulative improvement rate of 92.9%, 8-month cumulative recovery rate has reached 98.2 %, therefore, the cumulative improvement rate of 50% between 2-3 months and, according to statistics showed that the median bias in the 3, so the whole group of patients with pulmonary tuberculosis in patients with improvement time (MST) for 3 months. Log-rank test using the single factor analysis indicated that gender, age, diploma, history of TB treatment, the length of anti-TB program, complications, blood neutrophil percentage of these seven factors on the impact of cumulative improvement rate was statistically significant (P <0.05), while smoking, sputum tuberculosis bacteria levels,liver function damage these three factors on the cumulative improvement rate was not significant. Multivariate analysis showed that age, length of anti-tuberculosis programs,on the cumulative improvement rate was statistically significant (P <0.05)Conclusion: 50% of patients with sputum negative pulmonary tuberculosis and chest lesions began to absorb and stability must take 3 months , although they did not meet the standard of completely cure, remains to take anti-TB drugs, but patients have a better show about time and the probability of getting better, although in the course of treatment, age,are one of the major factors that can not changed, but as long as conditions get more attention to the first 3 months of visitations and 8 months of the full course of treatment, the early implementation of the joint, law, full, adequate anti-TB method, we can obtain more rapid sputum negative pulmonary tuberculosis patients, early lesions absorption,high cute rate and improve prognosis.
Keywords/Search Tags:survival analysis, tuberculosis, cure rate
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