| Objective: To clarify the evaluation of insulin resistance and pancreaticβ-cell functions in Type-2 diabetic patients. Methods: 138 patients with Type-2 diabetic were admitted in our hospital underwent OGTT and were classified by age, course, body mass index (BMI) , glycosylated hemoglobin, ethnic group, HOMA-IR, HOMA-βand△I30/△G30 of different groups were statistically analyzed by SPSS17. 0. Results: Age doesn't affact insulin resistance and pancreaticβ-cell functions, Insulin secretion, insulin resistance and pancreaticβ-cell functions defect were aggravated following course lengthen; As BMI gains, insulin secretion, insulin resistance and pancreaticβ-cell functions also elevated; With the elevation of glycosylated hemoglobin, plasma glucose elevated, insulin secretion reducted and pancreaticβ-cell function also down regulated. Compare with Han, Uygur has higher fasting plasma glucose?insulin secretion?insulin resistance index. Conclusion: If course is longer than 10 years; BMI is greater than 30kg/m2, glycosylated hemoglobin is greater than 11%, the insulin resistance and pancreaticβ-cell functions have obviously change, Uyger people has obvious hyperinsulinemia and insulin resistance, but theirβ-cell function does not change significantly. |
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