| Objective:To investigate protective effect of total flavonoids of Hipopophae rhamnoides L. subsp. turkestanica Rousi (TFH) on adriamycin-induced cardiotoxicity. Methods:60 SD rats were divided into six groups randomly receiving intragastric normal saline, three TFH (75,150,300mg/Kg) and Shengmai injection group once a day. Simultaneously, ADR group and three TFH froups were intraperitoneally administered with 5mg·kg-1 ADR every other day, totally five times. After the last dosage, the rat hearts were surgically removed then myocardial glutathione peroxide (GSH-Px) activity, superoxide dismutase (SOD) and malondialdehyde (MDA) content were determined and the myocardial ultrastructure was observed under electron microscope. Results: Compared with control, MDA was increased (P<0.05), while myocardial GSH-Px and SOD activities were decreased by ADR (P<0.05), respectively. Pathologic changes of myocardial ultrastructure were also observed in ADR group. In contrast, administration of TFH significantly increased myocardial GSH-Px and SOD activities and decreased MDA content (P<0.05), in addition, caused less ultrastructure changes of heart. Conclusion: TFH can protect the heart againist ADR cardiotoxicity caused by ADR,which mechanism is associated with antioxidant deficit. |
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