| Objective:On post-stroke depression (PSD) in the systematic analysis of Western literature, the subject of observation from a clinical point of view Xiaoyao post-stroke depression (qi stagnation) the treatment of patients. This randomized controlled trials, the treatment of post-stroke depression Modified Xiaoyaosan the efficacy and safety objective evaluation, and thus widely used in clinical Modified Xiaoyaosan lay a solid foundation.Methods:This study selected First Hospital of Wuhan City neurology outpatient and inpatient departments were 68 cases met the inclusion criteria of post-stroke depression (PSD) patients. Treatment in order according to the balloting were randomly divided into two groups, treatment group 34 cases,34 cases in control group. Before treatment, two groups of gender, age, etiology, course and severity of depression, neurological impairment level and Barthel index after treatment there was no statistically significant difference (P> 0.05), comparable. Conventional therapy in Western medicine, based on the treatment group as the basic party to be flavored Xiaoyaosan treatment (Chai Hu 15g, White peony 10g, Atractylodes 10g, Poria 15g, Angelica 10g, Chuanxiong 10g, Shichangpu 15g, Turmeric 15g, Mint 6g, Ginger 3g, Licorice 6g, water decoction, Japan 1,2 times per dose sub-served, each 200ml), the control group fluoxetine capsules (brand name:Prozac, Eli Lilly company):20mg, per Gordon served the morning meal. In the treatment of 2,4,8 weeks before and after treatment respectively HAMD score, neurological deficit score, ADL index assessment, and evaluation of TCM syndromes (rating scale by two physicians who have received specialized training co-assessment); in the treatment of before and after 8 weeks treatment xue, urine, then routine, liver function, kidney function, ECG, and after treatment, adverse reaction monitoring, on Modified Xiaoyaosan stroke depression treatment efficacy and safety for observation.Results:Through clinical observation showed that, by the Hamilton Depression Rating Scale (HAMD) reduced rate of clinical assessment, treatment group, the total effective rate was 79.41% in the control group, the total effective rate was 76.47%, After treatment, the total efficiency through statistical P>0.05, no significant difference. Clinical effects of Chinese medicine, the treatment group, the total effective rate was 88.23% in the control group, the total effective rate was 79.14%, total effective rate in treatment group compared with control group (P<0.05). HAMD score changes before and after treatment, HAMD score after treatment were significantly reduced. Compared with before treatment, treatment group in the HAMD score decreased after 2 weeks of treatment, compared with that before treatment, the difference was statistically significant (P<0.05); control group 4 weeks after treatment HAMD score began to decrease, compared with that before treatment ratio, the difference was statistically significant (P<0.05); in the treatment of 2 weeks,4 weeks HAMD score between the two groups was statistically significant (P<0.05), treatment group than the control group; the two groups after 8 weeks of treatment HAMD this difference was not statistically significant (P>0.05). Speeding up the improvement of neurological deficit, the two groups was significant difference (P<0.05), treatment group than the control group. Ability to improve daily life in patients with PSD, the two groups was significant difference (P<0.05), treatment group than the control group. Adverse reactions in clinical applications, the observations show that the treatment group no significant side effects, while the control group were 6 cases (18.6%) had abdominal distension, constipation, insomnia, dry mouth, dizziness, nausea and discomfort.Conclusion:Use Xiaoyao treatment of depression after stroke, in Chinese medicine to improve patient symptoms, accelerate recovery of nerve function and the ability to improve daily life of patients than the control group, and the rapid onset and few side effects. |
PDF Full Text Request