Study Of The Correlation Of Raised Erosive Gastritis With Spleen-Stomach Damp-Heat Syndrome With Gastric G Cells,D Cells And Parietal Cells

Objective:Through the observation of the number of gastric G cells, D cells and parietal cells and the ratio of the number of G and D cells (G/D ratio) in the raised erosive gastritis (REG) with spleen-stomach damp-heat syndrome(SSDHS) and spleen-stomach weakness syndrome(SSWS), as well as the control group, this study aims to investigate the differences among the three groups mentioned above, and explore the relationship between the REG with SSDHS and the gastric acid secretion, furthermore to provide clinical and theoretical bases for REG prevention and treatment with integrated traditional Chinese and Western Medicine.Method:This study chose 65 REG patients, which consisted of 30 REG patients with SSDHS and 35 REG patients with SSWS.In addition, a control group with 11 cases were found. All the subjects with fasting for 10 hours received a gastroscopy examination. During the examination, a piece of mucosa collected from the gastric antrum was used to do a rapid urease test and a histological staining, to detect the existence of H.Pylori (Hp). Two pieces of mucosa were also collected, one from the gastric antrum used for immunocytochemical staining, and the other from the gastric body used for HE staining. Finally, the number of gastric G cells, D cells and parietal cells, as well as the G/D ratio were computed.Results:1 Compared with the control group, the number of the gastric G and D cells in the overall REG group, the REG group with Hp (REG Hp+) and the REG group without Hp (REG Hp") fell.However, significant differences were not found (P>0.05). There were no significant differences in the G/D ratio (P>0.05), either. Whereas, the gastric parietal cells in the three groups mentioned above were significantly fewer than those in the control group (P <0.01). Significant differences were not found (P>0.05) in the number of the gastric G, D and parietal cells as well as the G/D ratio between the REG Hp- group and the REG Hp+ group.2 Compared with the control group, the number of the gastric G and D cells in the REG group with mucosa atrophy and the REG group without mucosa atrophy decreased. However, there were no significant differences (P>0.05). Significant differences were not found in the G/D ratio, either(P>0.05). Whereas, the gastric parietal cells in the REG group with mucosa atrophy and the REG group without mucosa atrophy were significantly fewer than those in the control group (P<0.01). There were no significant differences in the number of the gastric G, D and parietal cells as well as the G/D ratio (P>0.05) between the REG group with mucosa atrophy and the REG group without mucosa atrophy.3 Compared with the control group, the number of the gastric G and D cells in the over-50-year-old REG group and the under-50-year-old REG group declined. However, there were no significant differences (P>0.05). Significant differences were not found in the G/D ratio, either (P>0.05). Whereas, the gastric parietal cells in the over-50-year-old REG group and the under-50-year-old REG group were significantly fewer than those in the control group (P<0.01). There were no significant differences in the number of the gastric G, D and parietal cells as well as the G/D ratio (P>0.05) between the over-50-year-old REG group and the under-50-year-old REG group.4 Compared with the control group, the number of the gastric G and D cells in the REG group with SSDHS and the REG group with SSWS dropped. However, there were no significant differences (P>0.05). Significant differences were not found in the G/D ratio, either (P>0.05). Whereas, the gastric parietal cells in the two groups were significantly fewer than those in the control group (P<0.01). There were no significant differences in the number of the gastric G, D and parietal cells between the REG group with SSDHS and the REG group with SSWS (P>0.05). Nevertheless, the G/D ratio in the REG group with SSDHS was significantly higher than that in the REG group with SSWS (P<0.01).5 Significant differences were not found in the number of the gastric G, D and parietal cells,as well as the G/D ratio,between REG Hp+ group and REG Hp- group(P>0.05),both in REG with SSDHS and SSWS.Conclusion:1 The gastric parietal cells in REG are fewer than those in the control group.2 Compared with the the control group, the number of the gastric G and D cells in the REG group decreases. However, significant differences have not been found.3 Significant differences have not been found in the G/D ratio between the REG group and the control group.4 The G/D ratio in REG with SSDHS is higher than that in REG with SSWS. However, significant differences have not been found.5 Significant differences have not been found in the number of the gastric G, D and parietal cells between the REG with SSDHS and the REG with SSWS.6 To treat the REG may be implemented on the basis of protecting the gastric mucosa.