| Objective:Of that radiation-induced esophageal injury is one of the importantcomplications of radiotherapy ,there are two main reasons: the first one is thatradiotherapy is one of the main methods of treating tumor in chest, and thesecond one is that the esophagus is near the mean line of the body. What is more,how to prevent and cure radication-induced esophageal injury has become one oftough problems needed to be solved.Dan zhen oil is a kind of experienced prescription deveolped by ProfessorShi Hen-jun specially for radiation-induced esophageal injury. Basing our beforeexperiments, we have proved that it can not only cut down the level of MDA, theexpression of the TNF-αm RNA , the expression of IL-8, and the expression ofTGF-βmRNA, but also sublimate the activity of SOD of the radiation-inducedesophageal injury in rabbits. What is more , these changes are advantageous forrepairing of tissues.To observe the influence of Danzhen oil on ultrastructure of acute radiationinducedesophageal injury in rabbits by transmission electron microscope (TEM)in our study. And these will bcome the previous basis for conducting systemresearch of its characteristics and action mechanism and the theoretical basis forclinical application of Danzhen oil. MethodMethods and Results:Methods: Thirty Chinese rabbits were randomly allocated to five groups: theA group is normal, the B group is to irradiate, the C group is to irradiate and tocure by Dan zhen oil, the D group is to irradiate and to cure by XuanfudaizheTang, the E group is to irradiate and to cure by KangfuXinye. The changes ofesophagus tissue would be observed after four days of using drugs. What is more,the pathological changes of esophagus in B and C groups, were observed by TEM.Results: The curing of C group is better than the other curing groups of D and E,and the levels of lipid droplet, the changes of intercellular space and cell swelling,the degrees of cell shedding, especially of chromosome in C group surpassed theB group. |
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