| Epilepsy is the most common disease in central nervous system,the disease incidence is 35/10 ten thousand in one year and the attack rate is 5‰by the epidemiological survey in every country.The total number of the epilepsy patients approximately will be thirty millions in the world.There will increase four hundred fifty thousands epilepsy patients and the total number will be nine millions in my courtry.60-80 percent of the epilepsy patients can be controlled by the routine anti-epileptic drug and 60 percent patients can relieve the symptome by treatment,but the effects will be not good as expected in a great deal of patients,this be called intractable epilepsy.Temporal lobe epilepsy(TLE) is the most commom of the intractable epilepsies.70-80 percent of the TLE is hippocampal sclerosis that is characterized by nerve cell decreasing or increasing,but 10 percent of the TLE patients have no obvious morphological change in brain.The very effective therapy is to resect the hippocampal and the anterior temporal gyrus by surgical intervention in the intractable TLE patients,but one of the keys which lead to operative success is that we can exactly determine the location of the seizure focus.Along with the diagnostic techniques of imageology are rapid developing,the location of the seizure focus became accurate more and more in imageology.The PET-CT that was invented in recent years has an important value in the diagnose and location of the seizure focus in TLE,but the PET-CT has limitations too.The common MRI has been thought as a better the imaging technique in the location of the seizure focus.but the common MRI has some limitations in displaying the seizure focus in the TLE patients who have no morphological changes.In the experiment we want to compare the brain of the TLE patients who have no morphological changes to the brain of the controls by functional magnetic resonance imaging.We search the different brain regions as the target structure of treatment.That will provide the new information for diagnosing,treating,observating the effect of TLE that was treated.Object:To analyze the change of the grey matter in temporal lobe of epilepsy patients by the voxel-based optimized morphometry and the individual brain atlases using SPM.Method:We acquired the high resolution images of thirty temporal lobe epilepsy and forty healthy controls subjects age and sex matched by the magnetization prepared rapid gradient echo sequence.Then the images were processed and the data were analyzed by the voxel-based morphmetry in SPM5 and the individual brain atlases using SPM.we apply SPSS16.0 to statistical analysis.Result:By comparing the EP group and the control group,VBM revealed that the grey matter reduce at different extent in bilateral cingulum-ant gyrus,left cingulum-mid gyrus,left thalamus,bilateral post-central-gyrus,left ant-central-gyrus,right temporal-inf and left temporal-sup.The whole grey matter in EP is less than that in the control.They all have significance statistical difference(P<0.05).IBASPM reveal that the voxel of bilateral cingulum-ant gyrus,left cingulum-mid gyrus,right temporal-inf and left temporal-sup in EP group is less than those of the control group.They all have significance statistical difference(P<0.05).There is no significant difference between the voxel of left thalamus,bilateral post-central-gyrus,left ant-central-gyrus in EP group and in the control(P>0.05).Conclusion:VBM and IBASPM display the whole grey matter reduced in temporal lobe of epilepsy patients without lesion and the encephalic region where the grey matter reduced ,hint the main positions of the seizure focus and provide the information for clinical precise treatment. |
PDF Full Text Request