The Application Of Real-time Ultrasonic Elastography In Differential Diagnosis Of Breast Lesions

Objective:This research is to explore the value of real-time ultrasound elastograph in differentiating malignant from benign breast lesions. According to ROC analysis, the rational cut-off of the ratio of traced area was selected.Material and Methods:192 patients with breast tumor were examined during October 2008 to June 2009 in Huashan hospital. All patients were female and average age is 45.6±13.2.The instrument was Simens ACUSON Antares and the probe frequency was from 5MHz to 13 MHz. The SPSS13.0 software were used to analyze the data.Results:1.The elasticity mark≥4 was defined malignancy. The sensitivity, specificity and accurate rate of ultrasound elastography and conventional ultrasound were 92.65%,73.39%,81.25% and 88.23%,87.90%,88.02%.2.By combination of the two techniques, the sensitivity, specificity and accurate rate were 88.23%,95.97%,93.23% and the specificity and accurate were better than any one used alone.3.According to ROC curve, the sum of sensitivity and specificity was largest when ratio of traced area is 1.65.So the ratio of traced area=1.65 was defined malignancy and the sensitivity, specificity and accurate rate were 76.47%,96.77% and 89.58%.4.28 patients with US-BI-RADS 4B by conventional ultrasound diagnosis were examined by elastography and the sensitivity, specificity and accurate rate were 70%, 88.89%,82.14% respectively.Conclusions1,Ultrasound elastography can be used to differentiate malignant from benign breast lesions and the specificity and accurate rate would be raised by combined diagnosis.2,The ratio of traced area can be used as diagnosis standard and the results was similar with conventional ultrasound.3,The ratio of traced area=1.65 can be used as cut-off for breast lesions diagnosis.