Clinical Pathological Study Of XIAP And XAF1 Expression In Cervical Intraepithelial Neoplasia And Cervical Carcinoma

Objective:Significance of XIAP and XAF1 expression in development and progression of cervical carcinoma will be investigated after XIAP and XAF1 expression were observed in normal cervical epithelium,cervical intraepithelial neoplasias,cervical carcinoma.Methods:Cervix tissue were collected including 49 normal cervical epithelium,53 cervical intraepithelial neoplasiaâ… (CINâ… ),41 CINâ…¡,44 CINâ…¢,51 cervical carcinoma, XIAP and XAF1 expression were assayed by immunohistochemical method, and relation of XIAP and XAF1 expression to clinical stage was analysized.Results:Immunohistochemical results showed that XIAP positive signal located in cell Nucleus, its expression positive rate were 26.56% (13/49),28.3%(15/53),31.7%(13/41),68.18%(30/44),76.47% (39/51) in normal cervical epithelium, cervical intraepithelial CINâ… CINâ…¡, CINâ…¢, cervical carcinoma. XIAP expressed significantly higher in CINâ…¢and cervical carcinoma than others. Expression positive rate of XAF1 were 77.55%(38/49),69.81%(37/53),75.61%(31/41),22.22% (8/44),27.5%(11/51) in normal cervical epithelium, cervical intraepithelial CINâ… , CINâ…¡, CINâ…¢, cervical carcinoma. XAF1 expressed significantly lowerer in CINâ…¢and cervical carcinoma than others. Further analysis showed there is significant relation between XIAP and XAF1 expression. There is no significant relation of XIAP to XAF1.Conclusion:(1) There is a difference in XIAP expression among normal cervical epithelium,cervical intraepithelial neoplasias,cervical carcinoma, XIAP expressed higher in CINâ…¢and cervical carcinoma than others which suggest XIAP overexpression involved in development of cervical carcinoma;(2)There is a difference in XAF1 expression among normal cervical epithelium,cervical intraepithelial neoplasias,cervical carcinoma, XAF1 expressed lower in CINâ…¢and cervical carcinoma than others which suggest XIAP hypo-expression was associated with development of cervical carcinoma; (3) There is a relation between XIAP and XAF1 expression; (4) In the study, there is no relation of XIAP and XAF1 expression to clinical stage.