The Expression Of CHK1 In Bladder Benign And Malignant Tissue And Its Significance

Objective:To investigate the relationship of expression of CHK1in human bladder benign and malignant tissue and its significance.Methods:immunohistochemistry was used to detect the expression of CHK1 in 40 cases of the human bladder transitional cell carcinoma tissue; and 20 cases of the human chronic cystitis tissue. Statistics was used to analyze the data. By comparing range and degree of CHK1 positive staining, judging the corrilations of CHK1 between each other.Results:The expression of CHK1 in bladder malignant tissue group was extremely stronger than in bladder benign tissue group (p<0.01). There was significant difference for CHK1 expression in cancer cells between superficial bladder cancer and invasive bladder cancer (p<0.05). There was also significant difference for CHK1 expression in different pathologic grade(p<0.05).Conclusions:(1)There was significant difference for CHK1 expression in different bladder tissue, and high expression in bladder cancer. (2)Be closely related with clinical stage and pathologic grade of tumor, CHK1 might be the ideal targets for bladder transitional cell carcinoma, And CHK1 might be significant in predicting clinical stage and pathologic grade.