| Objective: To understand the female infertility Ureaplasma urealyticum (UU) and Chlamydia trachomatis (CT) infections. Through the detection of cervical secretions and pelvic fluid UU, CT infections, and pathological findings combined with laparoscopic surgery, and explore UU, CT infection and the relationship between female infertility and infection characteristics, in order to improve the diagnosis and treatment of infertility provide some reference.Methods: Collect the female patients which suffering from infertility and laparoscopic surgical treatment at Union Hospital, Tongji Medical College of Huazhong university of Science and Technology from January 2008 to March 2009, also the male semen examination was normal. Testing the expression of UU or CT in the cervical secretions and the pelvic liquid. Detailed records of their previous relevant medical history. All patients were followed up to see the outcome after laparoscopic treatment and the pregnancy rate, analysis of statistical tests to the result and the treatment outcome, to examine the relevance.Results:1. 108 cases of patients, pelvic inflammatory disease infection (PID) 80 cases of infertility caused by cervical secretions UU, CT-positive rate of 40.0%, significantly higher than other causes of 28 cases of infertility caused by (10.7%), and the difference was significant (P <0.05).2. 108 cases of patients, 60 cases of secondary infertility, cervical secretions UU, CT-positive rate of 41.6%, significantly higher than primary infertility group, 48 patients (18.7%), and the difference was significant (P < 0.05).3. Followed up for one year, 108 patients were 30 cases of natural pregnancy, total pregnancy rate of 27.8%, 3 cases of spontaneous abortion, ectopic pregnancy, 2 cases after the 28th week of gestation and term delivery were a total of 25 cases. 3 cases of spontaneous abortion, UU infection were 3 cases, UU, CT both positive in 1 case; two cases of ectopic pregnancy in UU, CT was negative. Pregnancy group compared with non-pregnancy group, non-pregnant group of cervical secretions and pelvic fluid UU, CT were significantly higher than pregnant group, the differences were not statistically significant (P all> 0.05).4. On the detection of mycoplasma susceptibility of the result : doxycycline and josamycin strong antibacterial activity, its sensitivity rate on the UU were 100.0% and 93.9%, 80.4% were on the MH .Conclusion:1. The UU or CT infection of reproductive tract caused by pelvic adhesions, salpingitis, hydrosalpinx, pelvic inflammatory disease, etc are the common causes of female infertility.2. Female patients infected with the both pathogens are usually not apparent after the clinical symptoms and performance, and thus difficult to detect clinically. Resulting in persistent infection constantly repeated, prolonged diseases, and some can cause endometrial and oviduct of chronic progressive, or even permanent irreversible damage. Therefore, infertility patients should be recommended routinely UU and CT clinical test for early detection and appropriate treatment to avoid further aggravate pathogen infection.3. Judging from the data of this study, spontaneous abortion patients, all of the existence of UU infection, as pelvic inflammatory disease caused by infection with infertility due to pelvic liquid UU, CT infection caused by other reasons than the number of cases infertility and more so, still can not rule out some influence between these two possibilities.4. For patients with UU or CT infection therapy, must have a drug susceptibility test, and strict antibiotic treatment options based on the results, to avoid empirical medicine, and thus more conducive to the treatment of infections and better control of drug resistance. |
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