Analysis Of Safety And Efficiency Of Transurethral Resection Of Prostate On High Risk Patients With Macrosis Benign Prostatic Hyperplasia

objective To explore the effects of transurethral resection of prostate on related indexand quality of life of senior high risk patients with macrosis benign prostatichyperplasia Further,we plan to evaluate the safety and efficacy of transurethral resection ofprostate and summarize the key aspects of perioperative management experience to provideevidence for clinical treatmentMethods Forty-eight patients with benign prostatic hyperplasia were involved in thisstudy．They all underwent transurethral resection of prostate 5％malmitol was used asi~igation fluid during operation Heart rate(HR),me3xl arterial pressure mad central venouspressure were recorded before operation,during operation for 30 minutes,60 minutes andafter operation Electrolyte,blood glucose and hemorheology were determined beforeoperation,during operation for 60 minutes and after operation The International ProstateSymptom Score(IPSS),Quality of Life(QOL),prostate volume reduction(PVR)madmaximum urinary flow--rate(Qmax)were tested preoperation and postoperationResults During operation HR was not significantly different between every twostages(P>0 05)Mean arterial pressure in stage of T2 and T3 was obviously lower than T1 madduring operation for 30 minutes(P<0 05)Central venous pressure in stage of T3 wasobviously higher than T1 mad T2．Na+,K_mad C1。did not change significantly(P>0 05)Ca。'was significantly decreased in T2 and T3(P<0 05)Blood glucose were significantly increasedin T2 mad T3(P<0 05)There was significant decrease of the whole blood viscosity at high,middle mad low-shear rate,the whole blood reduced viscosity at high and low-shear rate,plasma viscosity,the index of RBC deformation,the index of RBC aggregation mad themaximum rate of platelet aggregation at T3 mad T2 compared with T1(P<0 05)HCT and theindex of RBC rigidity were significmatly different at T2 from TI(P<0 05)The whole bloodviscosity at high shear rate,plasma viscosity,HCT,the index of RBC rigidity mad themaximum rate of platelet aggregation were significantly different at T3 from T2(P<0 05)ESRand ESR equation quotient(K)was not significantly different between every twostages(P>0 05)The Intemational Prostate Symptom Score(IPSS),Quality of Life(QOL),prostate volume reduction(PVR)and maximum urinary flow--rate(Qmax)were significmatlydifferent between preoperation and postoperation(P<0 05) Conclusions 1 Irrigation fluid'S absorption was observed during transurethral resectionof prostate The change of hemodynaanic,fluid-electrolyte balance,blood glucose andhemorheology for those patients can be observed according to irrig~ion fluid'S absorption 2TURP is a safe and effective therapy for high risk patients with macrosis benign prostatichyperplasia if the monitoring of related index especially hemodynaanic,fluid-electrolytebalance blood glucose and hemorheology and corresponding measures are taken to deal withthemaUerintime...