Discussion Of Mechanism And Deformation On Small Jump Of Cell In Flow Chamber

The blood cell's movement is a very important physiological phenomenon in the blood vessels. It is not only related to the blood and the organism's physiological characteristics, but also closely linked to some diseases. By experimental observation, it has been found that Leukocyte will occur adhesion near the vessel wall when it moves in the blood vessels. Then, it will paste the vessel wall and roll forward. In the end, it will jump off the vessel wall in the process of rolling forward. This article is based on fluid-solid coupling method. Solid analysis use the nonlinear large deformation theory. Fluid analysis use the low Reynolds number theory. Through the numerical simulation, it analyze a single cell's velocity and deformation conditions affected by fluid, which cultured in a rectangular cavity, and obtain the following conclusions:1.Due to the influence of gravity, the cell in the flow chamber show a slow movement toward the bottom of the chamber. The cell don't directly land in the bottom face, but back to jump in a certain distance from the bottom. It is called the cell jump phenomenon. When the cell back to jump a certain height, it re-flows to the bottom of the chamber. It occurs bounce-back again in a certain distance away from the wall. The cell repeated this process continuously and the bounce-back appear continuously. Each cycle is the basically same process.2.When the cell's movement is changed suddenly, the cell's stress and velocity will occur oscillation change.3.The cell usually occur compression in upwind side and extension in downwind side, when the cell is affected by fluid in a certain direction. The downwind side extension is occurred, mainly due to the surface of this part affected by fluid shear stress more than the compressive stress in this time.