The Effect Of The Resting Heart Rate To Essential Hypertension And The Damage Of Target Organs In Middle And Young Subjects

Objective:To explore the relationship between the resting heart rate (RHR) and the hypertension, and the influence to the risk factors and the damage of target organs in essential hypertension of middle and young subjects. Methods:There were 144 hypertension patients in hypertension group and 160 healthy subjects in control group, testing the RHR and comparing the difference in the hypertension group and the control group. According to the level of the RHR meassured by electrocardiography in the hypertension group, they were divided into three groups:RHR1(<70bpm), RHR2 (70bpm80bpm) and systolic blood pressure (SBP), diastolic blood pressure(DBP), body mass index(BMI), fasting plasma glucose, blood fat and carotid intimal medial thickness were examined. Then count the case of the damage of target organs. The results of different groups'made contrast and correlation each other. Results:(1) The level of the RHR in hypertensive group was significantly higher than that in normal group (78.10±9.02bpm vs 70.81±10.28bpm,P<0.05). DBP in all groups showed a statistically significant difference (P<0.05), and increased with RHR increasing. But SBP has no significant difference in the three groups (P>0.05). (2) Correlation analysis showed that RHR was positively correlated with BMI(r=0.259,P<0.01),and also had positively correlated with FPG,(r=0.19, P<0.05); but the RHR didn't have correlated with TG, TC, HDL-C,LDL-C(P>0.05).(3)In essential hypertension patients, the proportion of complications of the hypertension was different in different RHR groups, RHR higher, the bigger the proportion of complications (P<0.05). CIMT increased with the RHR increasing. The difference of CIMT among RHR1, RHR2, RHR3 were significant (P<0.01), Compared with RHR1 group, the RHR2 group and RHR3 group presented higher levels of CIMT (P<0.01). There was significant positive correlation between RHR and CIMT in hypertensive group(r=0.237, P<0.01). conclusions:RHR was correlated to the level of hypertension, RHR was one of the risk factors to middle and young patients with essential hypertension, and was used as one of the indicators for screening target organ damage in hypertension.