The Study Of Relationship Between Polymorphism In BST1 Gene Rs4698412 And Sporadic Parkinson's Disease

Objective:To detect the prevalence of rs4698412 polymorphisms of BST1 gene in Chinese with sporadie Parkinson's disease and explore the association between them.From the perspective of molecular genetics to research the possible pathogenesis of Parkinson's disease.methods:We utilized PCR-Restricted Fragments Length Polymorphism (RFLP) and DNA sequencing to identify genotype of rs4698412 of BST1 gene in 744 sporadie Parkinson's disease patients (471 man and 273 women, their average age is 53.05±10.9 years old) and 743 unrelated healthy controls(434 man and 309 women, their average age is 52.34±12.1 years old),then carried out an association analysis.Results:1. Rs4698412 variant in BST1 gene get a statistieal difference in genotype and allele frequeneies between sporadic Parkinson's disease group and healthy control group(genotype:P=0.019,allele:P=0.004,OR=1.24,95%CI:1.036-1.526).2. There is also a signifieant difference in allele frequeneies between EOPD patient group and healthy control(x2=5.158,P=0.025), LOPD patient group and healthy control(x2= 6.155, P=0.014).3. There is no signifieant difference in genotype and allele frequeneies between EOPD patient group and LOPD patient group (genotype:P=0.025,allele:P=0.828).4. There is no signifieant difference in genotype and allele frequeneies between male patient group and female patient group (genotype:P=0.951,allele:P=0.788).Conclusion:Rs4698412 polymorphismin in BST1 gene is a possible risk for Chinese with sporadie Parkinson's disease,it is likely to increase sporadie Parkinson's disease's genetic susceptibility.