The Relationship Between Serum Neutrophil Gelatinase-Associated Lipocalin Level And Diabetic Nephropathy

Objective:To investigate the relationship between serum Neutrophil gelatinase-associated lipocalin (sNGAL) and the early stage of diabetic nephropathy.Methods:23 healthy subjects of control group,30 T2DM patient,36 early stage of diabetic nephropathy patient were selected.The serum level of NGAL was measured in each group.The correlations between sNGAL and BMI,WHR,HOMA-IR, FPG,hs-CRP were analysised.Result:â‘ The sNGAL levels in patient with DN were significantly higher than that in control and T2DM groups.â‘¡There were positive correlation between the sNGAL and FPG,hsCRP,HOMA-IR,UAER(P<0.05 or P<0.01).â‘¢Multiple regression showed UAER,HOMA-IR were equal predicators of sNGAL level and HbA1c,hs-CRP,sNGAL were equal predicators of UAER level.Conclution:The sNGAL is increased in the group of T2DM,which can predict the renal disease earlier than UAER.Sngal may help the docter treat a patient in time and it play a great role in prevent the development of diabetic nephropathy.