Investigation On Metabolic Syndrome And Its Components In Individuals In A Unit Of Staff In Lanzhou

With the development of social economy, the changes of life style as well as the acceleration of aging, population and the incidence rates of Metabolic Syndrome (MS) is increasing daily. MS has become a kind of new chronic disease and major problem in the public health. The main clinical consequence of MS is diabetes or atherosclerosis cardiovascular disease, which has become a serious problem threatening human health.AIMS:MS as an independent indicator of cardiovascular disease and 2-style diabetes are receiving much widespread attention. MS mainly includes such dangerous factors as the central obesity, the abnormal glucose metabolism, high blood pressure, the metabolism disorder of blood lipid and so on. The prevalence of MS in people underwent health care screening from September 2008 to December 2008 was calculated and analyzed according to three definitions.To understand the metabolic syndrome and the occurrence of correlated diseases. The researcher conducted the research among 3465 staff cadres in a unit of Lanzhou, among them 2030 are male and 1435 are female. Age from 18 to 78, and the average age is 39.89±8.61 year old. To investigate the prevalence of metabolic syndrome (MS) by diagnosis of MS of IDF, ATPⅢ(2005 revised), CDS (2007 revised), and its components in individuals in them. To learn the sensitivity and specificity of the three MS diagnostic criteria were compared using one of the three criteria for the relative standard.Methods:1. Select people aged 18 and elder in a unit of staff in Lanzhou were included in this study.2. Measures of the basic index of human body, mainly including weight, height, body mass index, waist, blood pressure and so on.3. Measure of bio-chemical index mainly assesses FPG, TC, TG, HDL-C, LDL-C and so on. 4. Auxiliary examinations include ECG, Chest X-ray, Abdominal type-B ultrasound and so on.5. Statistical methods to make statically analysis by SPSS 11.0, using(x±s) to indicate the data of statistics, using t to denote the comparison between groups, usingχ2 test to denote The rate of count data, the difference is considered to be significant when(p<0.05). The agreement of the prevalence of 3 MS definitions and their kappa values were calculated. The sensitivity and specificity of the three MS diagnostic criteria were compared using one of the three criteria for the relative standard.Results:1. Metabolic Syndrome:According to the diagnosis standard of MS by IDF, the incidence rates of a unit of staff in Lanzhou is 16.31%, in which the male incidence rates is 16.65%, the female incidence rates is 15.82%. The overall prevalence of MS according to ATPⅢ(2005 revised) is 24.65%, in which the male incidence rate is 28.28%, the female incidence rates is 19.51%. For CDS (2007 revised) criterion 12.38% were diagnosed as MS, with 14.29% males and 9.69% females. The male incidence rates higher than female's.2. Overweight/obesity:The investigation demonstrated that 43.06% is overweight/obese when calculated by IDF and ATPⅢ(2005 revised), in which the male incidence rates is 42.76%, the female incidence rates is 43.48%. For CDS (2007 revised) criterion 32.78% were diagnosed as overweight/obese, with 25.27% males and 14.36% females. The male incidence rates higher than female's.3. Hypertension:Hypertension has same diagnosis standard with ATPⅢ(2005 revised), IDF and ATPⅢ(2005 revised) diagnostic criteria. The prevalence is 35.27%, in which the male incidence rate is 42.56%, the female incidence rates is 26.62%. The male incidence rates higher than female's.4. Abnormal glucose metabolism:The prevalence of hyperglycemia were 7.42% for ATPⅢ(2005 revised) and CDS (2007 revised) diagnostic criteria (male 9.95%, female 3.83%), 11.37% for IDF criterion(male 14.53%, female 6.3%) respectively.5. Serum lipid abnormality:Using standard diagnosis of IDF, ATPⅢ(2005 revised) and CDS (2007 revised) diagnostic criteria the incidence rates high TG is 38.1%; Low HDL-C is 20.55%,22.14% and 16.59%, respectively.6. The ATPⅢ(2005 revised) and IDF criterion showed excellent consistency whereas the CDS(2007 revised) criteria showed poor consistency with the other two criteria.The consistent rate was 94.7% between ATPⅢ(2005 revised) and IDF definition,85.6% between IDF and CDS(2007 revised) definition, and 83.5% between IDF and CDS(2007 revised) definition. 7. The prevalence show that the prevalence of MS and its components in IDF was increasing accompany with aging. The prevalence of MS has significant increased in age from 45 to 64, when over 65 years old, the metabolic syndrome incidence rates reaches as high as 29.48%.Conclusion:1. The findings show that a unit of staffs metabolic syndrome incidence rates in LanZhou is high, is obviously higher than domestically formerly reported, access to the level of developed country.2. The unit of employees in Lanzhou prevalence of MS using ATPⅢ(2005 revised) has the highest standard, and the prevalence of men higher than women under these three criteria.3. The agreement of ATPⅢ(2005 revised) and IDF definition was very high, and the agreement of between CDS (2007 revised) and other two criteria were moderate.4. The prevalence show that the prevalence of MS was increasing accompany with aging.The investigation result shows the incidence rates of metabolism syndrome is obviously higher than domestically formerly reported, access to the level of developed country. The reveal the prevalence of metabolism synthesis in our country presents the growth the tendency, the target people are facing threaten of metabolism syndrome and related disease. This investigation is limited to demography characteristic, such as living in the north, the diet rich in salt and fat and so on. So the result still has certain limitation. AIMS:Subjects who were received health examination in 2008 were re-investigated in 2010, among whom 3414 were investigated again two years later.Among them 2009 are male and 1405 are female. Age from 20 to 80, and the average age is 39.89±8.61 year old. To investigate current situations of metabolic syndrome and related indicators through comparative analysis of them.Results:1. Metabolic Syndrome:According to the diagnosis standard of MS by IDF in 2010, the incidence rates of a unit of staff in Lanzhou is 20.83%, in which the male incidence rates is 20.91%, the female incidence rates is 20.37%. The overall prevalence of MS according to ATPⅢ(2005 revised) is 26.95%, in which the male incidence rate is 29.36%, the female incidence rates is 23.51%. For CDS (2007 revised) criterion 15.05% were diagnosed as MS, with 19.13% males and 9.23% females. The male incidence rates higher than female's. Compared with 2008, the prevalence of MS followed up.2. Overweight/obesity:The investigation demonstrated that 43.59% is overweight/obese when calculated by IDF and ATPⅢ(2005 revised) in 2010, in which the male incidence rate is 45.01%, the female incidence rates is 41.57%. For CDS(2007 revised) criterion 33.17% were diagnosed as overweight/obese, with 43.81% males and 17.96% females. The male incidence rates higher than female's. Increase in the prevalence of overweight/obesity was significant among men.3. Hypertension:Hypertension has same diagnosis standard with ATPⅢ(2005 revised), IDF and ATPⅢ(2005 revised) diagnostic criteria. The prevalence is 35.85% in 2010, in which the male incidence rate is 41.24%, the female incidence rates is 28.18%. Increase in the prevalence of hypertension was significant among women.4. Abnormal glucose metabolism:The prevalence of hyperglycemia were 9.30% in 2010 for ATPⅢ(2005 revised) and CDS (2007 revised) diagnostic criteria (male 12.44%, female 4.81%),13.57% for IDF criterion (male 17.11%, female8.49%) respectively. The change of glucose was statistically significantly.5. Serum lipid abnormality:Using standard diagnosis of IDF, ATPⅢ(2005 revised) and CDS (2007 revised) diagnostic criteria the incidence rates high TG is 38.1% in 2010; Low HDL-C is 23.44%,24.01% and 18.86%, respectively. The change of hyperlipidemia was statistically significantly.Conclusion:1. The prevalence of MS and its related disease in two years' time were increased in unit of employees in Lanzhou.2. More efforts needed to be done to intervent components of metabolic syndrome and related metabolic indicators.