| Objectives:To investigate the serum levels of MCP-1,MIP-1α, SCD40L, TNF-α, EGF, IL-8, IL-10, VEGF in psoriasis vulgaris and correlation with PASI, TCM S yndrome type and staging of disease.MethodsThe level of serum MCP-1, MIP-1, SCD40L, TNF-α, EGF, IL-8, IP-10 and V EGF were measured by ELISA in 62 patients with psoriasis vulgaris and 20 normal controls. And discussed their relationships with PASI scores, TCM sy ndrome type and the staging of disease.Result1. The level of serum EGF in the patients of psoriasis vulgaris was h igher than normal controls, between the 2 groups were not statistically s ignificant (P>0.05). The higher EGF serum level in the difference types o f TCM syndrome, staging disease and PASI scores were statistically insign ificant(P>0.05), but it was correlated with the course of disease(P<0.0 5).2. The level of serum IL-8 in the patients of psoriasis vulgaris was h igher than normal controls.The blood stasis group type most representativ e of significance (P<0.01). The higher IL-8 serum level between blood stasi s and normal control group, blood dryness and normal control group were bo th with statistical significance(P<0.01), but were not significant correl ated to the staging of disease, PASI scores, course of disease (P>0.05)3. The level of serum IP-10 in the patients of psoriasis vulgaris was higher than normal controls.The blood stasis group type most representat ive of significance(P<0.01). The higher IP-10 serum level between blood st asis and normal control group, blood dryness and normal control group were both with statistical significance(P<0.01).The higher IP-10 level was co rrelated to the age and sexual distinction(P<0.05), but not to the staging of disease, PASI scores and course of disease (P>0.05)4. The level of serum MCP-1 in the patients of psoriasis vulgaris and blood stasis were higher than normal controls, between the 2 groups were not statistically significant (P>0.05). The higher EGF MCP-1 serum level in the difference types of TCM syndrome, staging disease,PASI scores and course of disease were statistically insignificant(P>0.05), but it was c orrelated with the sexual distincion(P<0.05).5. The level of serum MIP-1αin the patients of psoriasis vulgaris wa s higher than normal controls(P<0.01). The blood stasis group type most re presentative of significance(P<0.01). The higher MIP-1αserum level betwee n blood stasis and normal control group, blood dryness and normal control group were both with statistical significance(P<0.01). The level of serum MIP-1αwas not significant correlated to the staging of disease, PASI sco res and course of disease (P>0.05)6. The level of serum TNF-αin the patients of psoriasis vulgaris was higher than normal controls(P<0.01).The higher TNF-αserum level between blood stasis and normal control group, blood dryness and normal control g roup were both with statistical significance(P<0.01). The level of serum T NF-αwas not significant correlated to the staging of disease, PASI scores and course of disease (P>0.05)7. The level of serum VEGF in the patients of psoriasis vulgaris was higher than normal controls, between the 2 groups were not statistically significant (P>0.05). The higher VEGF serum level in the difference types of TCM syndrome, staging disease and PASI scores were statistically insi gnificant (P>0.05), but it was correlated with the course of disease(P<0.0 5).8. The level of serum IL-17 in the patients of psoriasis vulgaris was lower than normal controls, between the 2 groups were not statistically significant (P>0.05). The paracmasis between slationary phase and stadium augmenti were significant correlated(P<0.01). The lower IL-17 serum level was not correlated to the PASI scores and course of disease (P<0.05).9. The level of serum SCD40L in the patients of psoriasis vulgaris wa s lower than normal controls. The blood dryness group type most represent ative of significance(P<0.05). The lower SCD40L serum level was not signif icant correlated to the staging of disease, PASI scores and course of dise ase (P>0.05)Conclusion1. The serum EGF levels with psoriasis vulgaris were higher than norm al controls, and correlated to the course of disease.2. The serum IL-8 levels with psoriasis vulgaris were higher than nor mal controls which can be used as TCM clinical syndrome indicator of the micro reference.3. The serum IP-10 levels with psoriasis vulgaris were higher than no rmal controls which can be used as TCM clinical syndrome indicator of the micro reference. There was significant correlation between the serum IP-10 levels and the age, sexual distinction.4. The serum MCP-1 levels with psoriasis vulgaris were higher than no rmal controls which can be used as TCM clinical syndrome indicator of the micro reference. There was significant correlation between the serum IP-10 levels and the age, sexual distinction.5. The serum MIP-1αlevels with psoriasis vulgaris were higher than n ormal controls which can be used as TCM clinical syndrome indicator of th e micro reference.6. The serum MIP-1αlevels with psoriasis vulgaris were higher than n ormal controls which can be used as TCM clinical syndrome indicator of th e micro reference.7. The serum VEGF levels with psoriasis vulgaris were higher than nor mal controls which were correlated to the staging of disease.8. The serum IL-17 levels with psoriasis vulgaris were lower than nor mal controls which were correlated to the changes of dieases.9. The serum IL-17 levels with psoriasis vulgaris were lower than nor mal controls which can be used as TCM clinical syndrome indicator of the micro reference.10. The changes of serum cytokines play an important role in the path ogenesis of psoriasis vulgaris, which may have some positive regulations. |
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