Changes In Liver Function And Related Factors Of Donors In Living Donor Liver Transplantation (LDLT)

Background/Aims:Intra-operative cholangiography (IOC), the possible heat and mechanic injury during hepatectomy and the loss of liver volume may lead to a concern for the donor safety in living donor liver transplantation (LDLT). We aim to determine the dynamic change of liver function caused by IOC and parenchymal resection, and to assess its influence on the outcome.Methods:The information of 40 patients who donated the right lobes for LDLT were recorded and analyzed. The serum levels of biochemical values including total bilirubin (TB), aminoleucine transferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and y-glutamyl transpeptidase (GGT) were obtained at different time points (pre-operation, pre-IOC, post-IOC, pre-hepatectomy. post-parenchymal resection and post-operation) were compared.Results:The mean ALT. AST. TB,ALP and GGT value was 21.1 U/L,23.2 U/L. 12.7umol/L,47.2U/L,14.4U/L at the begin of operation, and changed to 33.3 U/L,37.4 U/L,12.0umol/L,44.0U/L,14.4U/L after IOC,51.6 U/L,60.1 U/L,10.5 umol/L, 39.2U/L,14.2U/L after parenchymal resection,63.1 U/L,74.9 U/L,12.2 umol/L,38.4 U/L,14.0U/L at the end of operation,28.4 U/L,25.5 U/L,12.6 umol/L,42.7U/L, 16.1U/L on 7 day post-operation, respectively. The ALT and AST values were significantly increased after IOC (P< 0.001) and arenchymal resection (P< 0.001).But TB, ALP and GGT values did not differ significantly. However, the biochemical changes caused by IOC or parenchymal resection did not correlate with the degree of post-operative liver injury or the recovery of liver function (P>0.05).Conclusion:IOC and parenchymal resection can lead to a transient increase of liver enzymes, but do not affect the recovery of liver function after operation.