Analyze Prognosis Of Patients Infected By Carbapenem-Resistant Klebsiella Pneumoniae In ICU

ObjectiveTo investigate and analyze prognosis of patients infected by carbapenem-resistant Klebsiella pneumoniae (CRKP) in ICU, which can provide a reliable basis for clinical treatment.Methods(1) 82 strains of Klebsiella pneumoniae were identified and their source distribution was analyzed. These strains were derived from bacterial cultures collected in ICU of 2nd affiliated hospital medical school of Zhcjiang University between January and December 2009.(2) Identification of bacteria was completed using VITEK systems of Merieux,France. Experiments in drug sensitivity were carried out using agar dilution diffusion test methods.(3) 47 patients infected by CRKPin hospital were divided into Carbapenem-resistant patient group and non Carbapenem-resistant patient group. For both groups, fatality rate, days in ICU and using a life-support machine were analyzed.Results(1) strains of Klebsiella pneumoniae derived from sputum were the predominant, accounting for 54.88 percent of the total number, and then closely followed by blood, drainage-fluid, bile, wound secretion, the tip of deep vein vessel and puncture fluid.(2) Compared with non Carbapenem-resistant patient group, for patients infected by CRKP, prognosis was poor, fatality rate was as high as 76% and significant difference was displayed (p<0.05); days in ICU extended and significant difference was displayed (p<0.05); days using a life-support machine extended and significant difference was displayed (p<0.05).ConclusionsFor patients infected by CRKP in ICU, prognosis was poor, fatality rate was high, days in hospital and using a life-support machine were obviously prolonged; Careful control of antibiotics, timely and effective identification of bacteria and drug sensitivity tests, early detection of Klebsiella pneumoniae infection will provide a reliable basis for clinical treatment.