Study On Modulating Lipidemia And Anti-Inflammation On Dehydrolovastatin

ObjectiveThe purpose of this article was to investigate the hypolipidemic and antiinflammatory effects of dehydrolovastatin(DLVT) in rats and in mice.MethodsRat hyperlipidemic model was established through feeding high fat diet and blood lipid levels were determined with automatic biochemistry analyzer after a certain amount of DLVT were administered ig once a day for 12 weeks. The pathomorphology of hepatic tissues was observed by microscope with staining HE slices. The anti-inflammatory effects of DLVT were also evaluated using xylene-induced ear skin inflammation model,cotton ball implantation-induced granuloma model,and adjuvant arthritis in mice.ResultsThere existed a time-dependent decrease of TC and LDL-C levels and improvement of liver pathomorphology in DLVT -treated (12 mg·kg^-1·d^-1)rats. Treatment of DLVT(8.4 and 16.8 mg·kg^-1·d^-1)significantly inhibited acute inflammation on ear skin induced by xylene, chronic granuloma inflammation caused by cotton ball implantation,and primary and secondary inflammatory arthropathy caused by AA mice with decreasing multiple arthritis indexes,improving standing and climbing abilities,reducing spleen cell proliferation stimulsted by LPS, blunting elevation of TNF-α, IL-6, IL–1,and NO,and suppressing fibroblast proliferation, synovial hyperplasia,and inflammatory cell infiltration in articles.ConclusionsDLVT has a similar modulation effect of reducing serum TC and LDL-C level and preventing the formation of fatty liver to lovastain. DLVT can also inhibit acute and chronic inflammation, and has a therapeutic effect on experimental AA mice.