The Investigation On The Relationship Between Angiotensinâ…¡ And Adiponectin, Pancreatic Islet Beta-Cell Secretion Function In Type 2 Diabetes Mellitus Patients

Objective: To investigate the relationship between angiotensinⅡand Adiponectin, the secretion function of pancreatic islet beta-cell in subjects with different glucose tolerances.Method: Forty-two patients with newly diagnosed type 2 diabetes mellitus (T2DM group), 38 subjects with impaired fasting glucose/impaired glucose tolerance (IFG/IGT group) ,and 40 normal control subjects (NGT group) underwent intravenous glucose tolerance test. Fasting plasma angiotensinⅡ( AngⅡ), adiponectin (ApN) was assayed by ELISA. Acute insulin response from 3 to 10 minute (AIR_3-10), that is the average insulin increment beginning the trial from 3 to 10 minute, the area under the curve (AUCⅠ) and the Peak Concentration (Cmax) of the first-phase (0-10min) insulin secretion, the area under the curve of the second-phase insulin secretion (AUCⅡ), homeostasis model assissment for beta-cell function index (HOMA-β) and for insulin resistance index (HOMA-IR) were calculated to explore the relationship with AngⅡ.Result:①The levels of AngⅡin T2DM group and the IFG/IGT group was significantly higher than those in NGT group (p<0.05); The AIR_3-10, AUC_Ⅰand Cmax, AUCⅡ, ApN in T2DM group and the IFG/IGT group were significantly lower than those in the NGT group (p<0.05), and these result were more significantly reduced in T2DM group compared with those in IFG/IGT group;②A ngⅡwas significantly negatively correlated to AIR_3-10, AUC_Ⅰand Cmax, AUCⅡ, ApN, HOMA-β(p<0.01), and positively correlated with fasting blood gluose, 2-hour postprandial blood glucose, fasting insulin, HOMA-IR (p<0.05);③Multiple stepwise regression analysis showed that AngⅡwas independently associated with AUC_Ⅰand AUCⅡ.Conclusion: AngⅡwas an independent factor that affected the insulin secretion function of pancreatic islet beta-cells. Ruling out the effect of blood pressure, body position, drugs and other factors, high levels of AngⅡcould predict the dysfunction of pancreatic islet beta-cell as well as insulin resistance in patients with type 2 diabetes.