314 Cases Chronic HBV Infection In Familial Aggregation Of Syndromes Research

ObjectiveThe exploration of the familial aggregation of chronic hepatitis B infection represent correlation of behalf of TCM and indicators of disease resistance, disease position, Pathogenesis, virus serum markers and liver function. The traditional Chinese medicine and Western medicine syndrome type detection index cross-references to supplement the micro-differentiation index. According to the observation of the laboratory, this paper explore the essence of TCM, and offer an objective basis for the the clinical syndrome of chronic hepatitis B.MethodsBased on the chronic hepatitis B with regularity Syndrome Case Report Form (CRF) from research group, I collected the medical records of patients hospitalized with chronic hepatitis B in Traditional Chinese Medicine Hospital in Sichuan Province, Infectious disease hospital in Chengdu and West China Hospital outpatient clinic. The imformation of four diagnostic from CRF has been obtained by the two or more experts Syndromes. In the meantime all of the Western diagnostic criteria, inclusion criteria and exclusion criteria of patients with chronic hepatitis B were researched respectively reference to the "prevention and treatment of chronic hepatitis B Guide" which was developed jointly by the Chinese Medical Association Hepatology Infectious Diseases and Chinese Medical Association on December 2005 and according to 314 patients with family infection and 601 patients without family infection. this paper inspect and record HBV and Liver function values, statistics with spssl3.0 the software for medical statistics. Measurement data first test of homogeneity of variance; more when homogeneity of variance among groups, with pairwise comparison analysis of variance and q test; compared with the number of sample rank sum test; count data between multiple sets of R×C test, two group comparison between the rate of use of split testing.ConsequenceI collected a total of 915 patients of which 314 copies of the history of HBV infection in the family, no history of HBV infection in 601 family. By statistics, (1) Group with HBV infection family history is mainly about spleen deficiency syndrome and liver spleen deficiency syndrome。Group without family history of HBV infection is mainly about spleen deficiency and liver stagnation syndrome heat. (2) I compared the group with HBV infection family history and Group without family history of HBV infection, and had following result:significant differences in disease(P<0.05), Location and symptoms of disease have no difference(P>0.05); Hepatitis B markers were significantly different(P<0.05), HBeAg-positives is common in the group with history of HBV, and HBeAb-positives is common in the group without history of HBV.(3) There is apparently different syndrome between the group with HBV infection family history and group without family history of HBV infection in average age, HBV, HBV DNA Load, aminotransferase, bilirubin and serum protein.(P<0.01)(4)Correlation Analysis of group with family history of infection in verage age, HBV, HBV DNA Load, aminotransferase, bilirubin and serum protein has apparent difference.ConclusionHBV infection in the family is mainly about spleen, liver and kidney. Where the relationship of kidney is more closer than those without HBV famaly. Disease resistance is mainly about both spleen deficiency. Spleen deficiency syndrome and liver depression and spleen are the most common disease type with the age is mainly between 30-40 years old.And Deficiency syndrome of those without HBV imfection is younger significantly.HBeAg positive has higher rate than HBeAb, HBV DNA replicate actively and TP has a significant correlation between ALB. All of above has no correlation with Transaminase and bilirubin index.But it has obvious correlation between index' rise of damp heat retention syndrome ALT, AST, TBIL, DBIL, IBIL.