Clinical Research Of Target-controlled Infusion Of Propofol In Painless Endoscopy

Background:Gastroscopy has become the conventional methods of examination and treatment of digestive system, due to its operations caused by stimulation in patients with severe adverse reactions, and brought fear and trauma, all increase the risk of checking, limit the feasibility of gastroscopy. Therefore, painless gastroscopy develop rapidly in recent years. Gastroscopy has occupied oral channel, check time shorter, more features of outpatients, will need to anesthesia induction and maintain as much as possible to maintain stable life in, the check is completed as soon as possible so that patients in a short time after waking up, so as to improve gastroscopy turnover. To this end, anesthesiologists have made a lot of experimental study.Objectives:Explore Eyelash reflection effect disappeared with optimal mirror effect site concentration.Methods:Choose 180 outpatient painless gastroscope inspection patients case, age 20 to 60 years old, ASAⅠ～Ⅱlevel. Randomly divided into three groups, each group of 60 people. According to different patient's age and weight, set target controlled concentration of propofol in 6.0ug/ml to induce anesthesia. Observe and record patient eyelash corresponding effect site concentration reflex disappears, and in the eyelash reflex disappears, to 0.1μg/kg injection of fentanyl. A group of patients with endoscopic insertion effect site concentration in patients with Eyelash reflex disappears when effect site concentration of 1.5 times, B group of patients with endoscopic insertion effect site concentration in patients with Eyelash reflection vanishing twice times the concentration, C group in patients with endoscopic insertion effect site concentration in patients with Eyelash reflex disappears when concentration of 2.5 times. Gastroscope smoothly after the Insert, will maintain the concentration of target-controlled settings for Eyelash reflection effect disappeared twice times the concentration. Return mirror stops when the infusion. Anesthesia and analgesic effects of three groups of patients to rate, observed and recorded in three groups of patients before anesthesia, surgery changes in HR, RR, SpO2, recorded in the endoscopic operation when inserting objects or in patients with hypoxemia. Recorded waking time targeted response time.Results:Between the three groups of operative procedure on gender, age, height, weight, time, and there were no differences of stimulus intensity operation (P>0.05). Before anesthesia between three groups of mean arterial pressure, heart rate and blood oxygen saturation are not statistically significant differences (P>0.05); after the anesthesia, three groups of mean arterial pressure, heart rate and blood oxygen saturation, there are significant differences. And b group compared,-a group (is into mirror concentration for eyelashes reflection disappeared Shi effect room concentration of 1.5 times times) average artery pressure, and heart rate increased more, has statistics differences (P<0.05); and b group compared, c (is into mirror concentration for eyelashes reflection disappeared Shi effect is concentration of 2.5 times times) group average artery pressure, and heart rate, and blood oxygen decline range larger, has obvious differences (P<0.01). Which, in gastroscope insert during, and b group compared,-a group (is into mirror concentration for eyelashes reflection disappeared Shi effect room concentration of 1.5 times times) body dynamic reflection of occurs rate obvious than b, has statistics differences (P<0.05), and c Group (is into mirror concentration for eyelashes reflection disappeared Shi effect is concentration of 2.5 times times) of low oxygen blood syndrome of occurs rate far over b group, has obvious differences (P<0.01). Three groups of atropine basic no differences in the use of ephedrine. After inserting gastroscope incidence among three groups of dynamic response of patients with hypoxemia and have no significant statistical differences in the incidence of. Gastroscopy revived after the end of time no differencesConclusion:Endoscopic insertion and effect site concentration for Eyelash reflex disappears when effect site concentration twice times, can effectively control undesirable reflections, and would not result in prolonged recovery time.This anesthesia is best.