| Objective: To underatand the detailed information of people who HCV-?infection in Fuyu Town,and to prove the correlations between FibroScan results and other factors.Background: Hepatitis c is one of the infectious diseases which is serious threatening to human health,it mainly through blood spread. According to statistics ,there are 1.7 million people have be infected all over the world. Hepatitis c infection rate is about 3.2% in China. Parts of fuyu county because of geographical location and historical background, humanistic habits, and other factors.Before 1990s,those people took much use of the nondisposable syringe injecting″Benzoic acid caffeine″.And there are a considerable number of people use the syringe injection antipyretic analgesics or antibiotics. Hepatitis c virus infection significantly in the region is more than in other regions.Our department had sent staff here to investigate the actual situation from September 2009 to May 2010,among the survey 828 villagers, there are 409 people anti-HCV positive ( 49.40% ).Historically,liver biopsy has been considered the only diagnostic method for the assessment of liver fibrosis. However, it is an invasive and painful procedure with potential life-threatening complications,including bleeding, perforation of other organs, and death, which sometimes limit its acceptance and repetition. At present ,doctors application liver fibrosis serodiagnostic indicators in clinical include: 1. procollagen III N-terminal peptide, PIIINP ; 2. Laminin,LN; 3. Collagen type IV ; 4. Hyaluronicacid, HA ; 5. matrix metalloproteinases, MMPs. Results easily influenced by other factors. With ultrasonic technology developed liver tissue determination method of elastic or stiff degrees, called transient elastography:FibroScn . As a new kind of liver fibrosis testing method, comparing with traditional fibrosis diagnostic methods,it shows more specificity, accuracy and repeatability.Method:We select Gengxin rural and Yijiadian rural in Fuyu Town as survey site and adopt a uniform face to face questionnaire. The survey include the basic information such as age, sex, smoking history, drinking history, history of hepatitis, blood transfusion, blood donation history, history of injection of caffeinum natrio benzoicum, people around you have a caffeinum natrio benzoicum injection history, history of tooth repair, previous history of hepatitis C treatment and so on. Check item: FibroScn and color dopplar ultrasound.Sample test items: blood routine,hepatitis C virus antibody (anti-HCV), and liver function,HCV-RNA. Simultaneously according to serological indicators and patients basic information noninvasive fibrosis model calculation: AAR,APRI,API,FIB-4 and S INDEX.Results: 19 cases among all the people have unsuccessful LSM(Liver Fibrosis merasure).When all of them extended check side torsorib,their gap width were≤9mm. Among these 19 cases there are 7 people BMI≥25. There are 838 people among all the people have successful LSM results。619 people have complete information on weight and height results. The average of their BMI is 23.17±2.74. Among these 619 volunteers there are 133 people's BMI≥25。The average age of the group who have no results is 52.11±9.69;11 people are more than 50 years old; 816 people have result and age data, the average age of them is 49.57±9.91, 409 people are more than 50 years old among them;when we set″t test″analysis on average ages of the two groups, the result was not statistically significant.There are 838 people have FibroScan results, the average of FibroScan results are 49.57±9.91,among them ,men 524,women 314; the success rate of FibroScan is 98.7% in men and 96.3% in women.There are 816 people have age datas, the average age of them is 49.57±9.91,the oldest men is 76 years old and the youngest men is 13 years old. 828 people have hepatic parenchymal color dopplar ultrasound results,the average color dopplar ultrasound score is 1.76±0.82.Assume the first appeared arbitrary HCV related contact time for infection time, set up the statistical analysis of Hepatitis c infection time and FibroScan results,except the group who HCV infection less than 10 years.FibroScan have results crowd, HCV negatie 194 people, including a mild fibrosis, moderate to severe fibrosis, cirrhosis with HCV positive people compare the number, with a statistical significance.FibroScan results of HCV negative groups are less than the results of HCV-infected 0~10 years group;FibroScan results of the group HCV-infected 0 ~ 10 years are less than the results of infected more than 10 years group (p < 0.05), FibroScan results of infected more than 10 years each group are without significant difference.FibroScan results have no correlation with HCV infection time; And gender, cholesterol, leukocyte in total, serum albumin weak negatively correlated; And cholinesterase, platelet count are low negatively correlated; With age, alkaline phosphatase, total protein, total bilirubin, virus is weak correlative quantitative XianZhuanTaiMei with gamma - glutamine, cereal third transaminase, liver exceeds are low positive correlation.FibroScan results and APRI, FIB - 4, S - INDEX are significant positive correlation;and are low positive correlation with API;,and are weak positive correlation with AAR.Conclusion: FibroScan success rate and body mass index, Rib gap width has close relations.Humen whose BMI≥28 or Rib gap width≤9mm would lead to detection failed. Liver fibrosis degree and infection time had related. FibroScan results and ALT numerical has certain correlation.FibroScan results and APRI, FIB - 4, S index has high correlations. |
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