Correlation Between The Chemotherapy Resistance Of Of Diffuse Large B-cell Lymphoma And Cytokines IL-6 And IL-10

Objective:To investigate the correlation between expression levels of serum cytokines IL-2, IL-6, IL-8, IL-10, TNF-αand IFN-y in patients with diffuse large B-cell lymphoma(DLBCL) and chemotherapy resistance.Methods:30 cases of DLBCL patients with chemotherapy resistant,30 cases of DLBCL patients with chemotherapy sensitive and 20 cases of healthy individuals as normal control group were enrolled. The levels of serum cytokines IL-2, IL-6, IL-8, IL-10, TNF-αand IFN-y before, during and after treatment in both DLBCL groups and normal control group were detected by ELISA assay.Results:The expression level of serum IL-6, IL-10 before treatment in DLBCL in patients with chemotherapy resistance were significantly higher than that in DLBCL patients with chemotherapy sensitive and normal control group (P<0.05), however, that after treatment in DLBCL patients with chemotherapy resistance was significantly lower than that before treatment (P=0.02 and P=0.015). The level of serum IL-6, IL-10 in patients with DLBCL recurrence into drug resistance was higher than that during of remission (P=0.004 and P＜0.001). Before treatment, the expression level of serum IL-6 in patients withⅢ-Ⅳstage in chemotherapy resistant group was significantly higher than that in ones withⅠ-Ⅱstage (P<0.05). Levels of IL-2, IL-8, TNF-α, IFN-γin chemotherapy resistant group, chemotherapy sensitive group and the normal control group were no differences. (P>0.05).Conclusion:The expression levels of the serum IL-6, IL-10 were closely correlated with the chemotherapy efficacy of DLBCL, they may be involved in drug resistance of DLBCL...