Cyclosporine Pretreatment On Aortic Valved Graft Protection

Valve vascular nature, blood centers and anti-reflux, low immunity, easy to form athrombus, attached to bacteria and other features not easily become complex congenital heart disease right(left) ventricular outflow tract of the main biological materials. But the clinical encounter often within the same valve as the degradation of abnormal[1] . Can also cause blood vessels after transplantation of allogeneic host immune rejection, the ultimate result of graft stenosis and occlusion of vascular allograft transplantation is a major obstacle. Allogeneic vascular rejection after transplantation, including immune cells and humoralimmunity, the immune response caused by intimal hy intimal hyperplasia of blood vessels can eventually lose their function. So before allogeneic vascular grafts pretreated to eliminate allogeneic antigens on blood vessels. Domestic and foreign scholars in reducing the immunogenicity of vascular allografts are a lot of research areas[2]. Pretreatment of tissues with cyclosporine, which had earlier applied the same vein of dogs, the treatment may improve graft survival, scanning electron microscope also found to reduce degeneration. This is an effective immunosuppressant cyclosporine has been used in clinical patient sunder going valve replacement of individual[3], because of serious adverse drugreactiond, the general proposition valve transplantion with caution. Large amounts of date have shown the same kind of flap after early use ofimmuno suppressive agents with anti-calcification,the mechanism is to inhibit the immune rejection early after transplantation,reduces the endothelial cells and smooth muscle cells by the immune attack and protect the endothelial cells and smooth muscle cells. Currently not been reported with cyclosporine pretreatment on the same valves and valve function in the control of the follow-up study.