To Study The Suitability Of Navel Transdermal Deliver System Which Used Glycerin Fatty Acid Ester As Matrix

Umbilical therapy is the umbilical cord in the hole by (the navel) administration or in the umbilical give some physical stimulation (moxibustion, and hot, etc.), for the treatment of human diseases. External treatment is one of chinese medicine can also be classified as modern medicine Transdermal therapeatic syste (TTS) category. Umbilical therapy is widely used in various systems on human diseases are reported in the modern clinical internal medicine, surgery, gynecology, child, blood, skin, health and other subjects the disease has its own unique medical effects. But the current administration in the dosage form of clinical umbilical still lags behind on the choice, continue to use traditional preparations, For powder plaster application, And modern compared to transdermal drug delivery preparations can not meet the clinical needs.Therefor, the use of modern technology on human umbilical in preparation on transdermal drug delivery points for the suitability study is of great significance.In this study, fat-soluble matrix - semi-synthetic fatty acid ester as drug delivery systems, respectively, the alcohol extracts of Chinese white paeony root and corydalits tuber based medicine into a paste prepared pastes, systematically study three relationships of drug, matrix, and penetration enhancers. By Franz diffusion cell in vitro penetration test carried out to clarify the fat-soluble Azone, water-soluble Azone and dimethyl sulfoxide and common umbilical transdermal absorption enhancers on transdermal drug delivery in the point of impact; reduction method to pharmacokinetic studies in humans,Umbilical administration proved over other parts of the skin absorption of the drug administration more advantages; on Paste to carry out the skin toxicology and pharmacodynamics clinical applications to protect the safety and efficacy; In addition, physical volume of normal adult umbilical, umbilical fossa internal temperature were measured in the hole for the navel preparation of transdermal drug delivery formulations provide a reference parameter. Through this experiment, illustrates a semi-synthetic fatty acid glyceride as navel paste matrix transdermal delivery system in the point of suitability for the preparation of modern technology in the umbilical transdermal drug delivery in the hole to provide technical support.