The Clinical Significance Of NGAL In Early Diagnosis Of Contrast Nephropathy Urine

Background:Now, along with coronary artery treatment technique (coronary angiography and coronary PCI) launched extensively, and its complications have been paid more and more attention. With the wide use of contrast, contrast nephropathy (nephropathy, induced up-CIN) has become a diagnosis of coronary artery after one of the most common complications. CIN hospital-acquired renal failure is in third place, the reason of the coronary artery CIN has become the strongest postoperative death of diagnosis and treatment of predictors. In the last few decades people to know and CIN pathogenesis of CIN prevent medical technology level has been greatly improved, but the morbidity and mortality CIN still high, a main reason of what cause this situation is the lack of effective early diagnostic markers. Detection of the most commonly used CIN index is still Scr concentration, because the concentration of Scr by weight, changes nutritional status, race, age, gender, and many other the nonglomerular factors, and the index dropped as renal Scr lacks sensitivity. So, how to make the diagnosis of early CIN and take early intervention to prevent kidney damage avoid kidney failure is a very important thing. Recent studies show that neutrophils gelatinases related gelatinase-apolipoprotein (neutrophil NGAL) is lipocalin, eliminate the most effective diagnosis acute kidney injury (one of the symbols of the biology.Objective:Through the determination of preoperative patients with coronary interention within 24h urine and postoperative 2h NGAL concentration, discusses in NGAL of coronary artery after interventional contrast nephropathy in the early diagnosis of clinical significance.Methods:Select our heart disease patients in May 2010-April 2011 using non-ionic low-osmolar contrast media on angiographic 60 adult patients, all patients respectively on coronary artery treatment within 24h preoperative and postoperative 48h serologic testing Scr. All patients respectively on coronary artery treatment within 24h, preoperative NGAL collect urine testing postoperative 2h. According to the patient in imaging 48h happened after CIN (whether by within for diagnosis index), Scr CIN group and not divided into CIN group.Results:CIN group of patients after coronary artery than 24h diagnosis preoperatively significantly increased 2h (p< 0.01)Conclusion:Coronary artery NGAL diagnosis can be as postoperative 2h urine CIN reference index early diagnosis...