The Expression And Significance Of HGF And MMP-9 In Lichen Planus

Objective: To explore the expression of hepatocyte growth factor(HGF) and matraix metallopro- teinase-9(MMP-9) in lichen planus,and investigate the function in pathogenesis of lichen planus.Methods: The expression of HGF and MMP-9 were assayed by RT-PCR and Immunohistoche- mistry in 30 LP lesions and 30 normal skins.Result: The expression of HGF and MMP-9 in LP lesions was stronger than in normal skins(p<0.01),and the relation of HGF was positively related to the expression of MMP-9 in LP lesions (r1=0.391,p1=0.032; r2=0.375, p2=0.041).Conclusion: The increased expression of HGF and MMP-9 may contribute to the formation and progression of lichen planus.