Changes Of Inflammatory Factors In Senile Hypertensive Patients With Postprandial Hyperglycemia And Acarbose Intervention

Objectivs To observe the changes of inflammatory factors in senile hypertensive patients withpostprandial hyperglycemia and effect of acarbose intervention.Methods Selected 120 out-patient untreated elderly(≥60years)in patients with grade 1 isolatedsystolic hypertension. All the patients were done 75g glucose tolerance test (OGTT) ,there are 65patients with hypertension and hypertensive patients with postprandial hyperglycemia are 55(fasting blood glucose <7.0mmol/L,2-hour postprandial blood glucose≥7.8mmol/L,<11.1mmol/L is IGT),and selected 50 cases of age, gender matching healthy check-up personas controls.Each object of study measured blood pressure, height, weight and calculated bodymass index (BMI).Asked patients with diabetes mellitus,hyperlipidemia,smooking history and soon.Blood tests,including fasting blood glucose(FBG),2-hour postprandial blood glucose(2hPG),total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C). Serum TNF-αand IL-6 levels were measured withRIA, hs-CRP level was measured with immunochemistry method compared three groups ofproinflammatory factor levels.In addition,55 cases hypertension with postprandialhyperglycemia patients were given acarbose 50mg,tid, after 12 weeks treatment detected threeserum levels of inflammatory markers and compared proinflammatory factor levels beforetreatment .Results1,Three groups in age, gender, body mass index, diastolic blood pressure, blood fat, fastingblood sugar aspects difference were not statistically significant (P > 0.05); systolic bloodpressure in hypertension group and hypertension with IGT group were significantly higher thancontrol group (P < 0.05), but comparison between them was not statistically significant (P >0.05);2-hour postprandial blood glucose in hypertension with IGT group was higher than controlgroup and hypertension group, the difference were statistically significant (both P< 0.05).2,Three proinflammatory factor levels in hypertension group and hypertension with IGT groupwere higher than control group, the difference were statistically significant (P < 0.05,P <0.01);hypertension with IGT group of three proinflammatory factor levels were higher thanhypertension group the difference were statistically significant (P < 0.05).Pearson correlationanalysis show that inflammatory factors and blood pressure,2-hour postprandial blood glucosewere positively correlated.3,hypertension patients with IGT were given acarbose intervention, after treatment ofproinflammatory factor levels were relatively lower than before treatment, the difference were statistically significant (P < 0.01).ConclusioConclusion1,Hypertension patients of inflammatory factor levels were significantly increased than normalcontrol group ,that explained inflammation may be involved in the hypertension somepathophysiological development process.2,Hypertensive patients with postprandial hyperglycemia of inflammatory factor levels werehigher than pure hypertensive patients, inflammatory reactions involved in hypertensive patientswith abnormal glucose metabolism pathophysiological process,and in the consolidatedpostprandial hyperglycemia inflammation is more obvious, may be it exacerbate progression ofatherosclerosis.3,Hypertensive patients with postprandial hyperglycemia application acarbose treatment,withglycometabolism improvement, the serum levels of proinflammatory factor also declined,thendelay the atherosclerotic process.