The Clinical Study Of Disharmony Between The Heartand Kidney Climacteric Insomnia With Anshen Decoction

Object: To observe the clinical effect of Anshen decoction treating the disharmony between the heart and kidney climacteric insomnia and others symptoms of climacteric syndrome.Methods: The 70 outpatients, which were according with diagnostic criteria and from June 2008 to May 2009, were randomly divided into the treatment group's (n=35) and the control group's (n=35). The treatment group's were treated by Anshen decoction by oral, on the while, the control group's were treated by estazolam tablets by oral.Compared two groups of outpatients before and after treatment clinical symptoms, Statistical analysis was conducted for them.Results: After a course of treatment, the treatment group's compared with the control group's, there was no significant difference (P<0.05) in the general efficacy. Before and after treatment, the treatment group's compared with the it-self and control group with it-self were significant difference in improving sleep (P<0.05). On the TCM (traditional Chinese medicine), treatment group's was significantly better than the control group's (P<0.05). Compared with that before treatment, two groups were significant difference at clinical symptoms in chinese medicine, Such as waves of thermal sweating, paresthesia, insomnia, irritability, headache, etc(P<0.05). But in fatigue, bone and joint, muscle pain, palpitations, skin formication and urinary symptoms, the treatment group's had significant difference(P<0.05). In the treatment of vertigo, the control group's there was significant difference compared with before treatment (P<0.05). On the level of neurotransmitter changes, The two groups of cases are to be a significant gender difference on the level of 5-hydroxytrytamine (5-HT) in the treatment before and after (P<0.05). But after treatment, the level of 5-HT of the treatment group's is not a significant difference with control group's (P>0.05).Conclusion:(1) the effects of Anshen decoction in improving the disharmony between the heart and kidney climacteric insomnia symptoms in outpatients were positive and obvious.(2)Anshen decoction had a good effect for improving other symptoms of climacteric.