Assessment Of Response To Therapy And Prognosis By Monitoring Of Minimal Residual Disease In Acute Myeloid Leukemia M₂

Objective :To find out the relationship of minimal residual disease(MRD) and cytogenetic characteristics in adult acute myeloid leukemia(AML) M₂.Methods : Immunophenotyping and the level of MRD using eukemia-associated immunophenotypic (LAIP)was analysed by multiparametric flow cytometry(MFC) in 117 adult M₂-AML.Results : Based on cytogenetic characteristics , 3 different prognostic categories were identified. The level of MRD has no difference in 3 different prognostic categories. In this group MRD levels were defined as high (≥5x10^-3) and low (<5x10^-3) level one year.The incidence of relapse were 29.4% and 8.8%, in the 2 groups, respectively, with a higher incidence among patients who were in MRD high level group than in those who were in MRD low group (P< 0.05).Conclusion: Immunophenotypical evaluation of MRD in M₂-AML can be reliably used to assess early response to treatment and predict relapse.