Correlation Between Serum HIF-1αand VEGF Level Pre-and Post-TACE In Patients With Primary Liver Cancer

Objective To investigate the expression and correlation of serum hypoxia inducible factor-1α(HIF-1α) and vascular endothelial growth factor (VEGF) level pre-and post-transcatheter arterial chemoembolization (TACE) in patients with primary liver cancer (PLC).Materials and Methods Expression of serum HIF-1αand VEGF were studied in 20 healthy volunteers as control group and 40 cases of PLC pre- and 1 day, 1 week, 1 month post-TACE.Results The expression of HIF-1αand VEGF was (154.94±83.29) pg/ml, (264.00±148.10) pg/ml pre-TACE, higher than those in control group's(23.84±8.15)pg/ml,(69.78±21.42) pg/ml (P<0.01); (570.64±230.87) pg/ml, (362.07±102.25) pg/ml in PLC patients 1 day post-TACE, higher than those pre-TACE (P<0.01); (198.62±92.11) pg/ml, (283.52±145.46) pg/ml 1 week post-TACE; (133.96±57.02) pg/ml, (150.96±84.89) pg/ml in the complete response (CR) group 1 month post-TACE and (255.74±123.44) pg/ml, (368.95±161.90) pg/ml in partial response (PR) and stable disease (SD) group (P<0.05). The expression of serum HIF-1αwas positively correlated with VEGF pre-TACE, and serum HIF-1αcorrelated with portal vein tumor thrombosis and metastasis and VEGF correlated with capsule, portal vein tumor thrombosis and clinical stage.Conclusion The expression of serum HIF-1αand VEGF play an important role in relapse of tumor, and contributes to the evaluation of the efficacy of TACE, metastasis of PLC and provid theory basement for using anti- angiogenesis drugs.