Study On The Association Of-838G/C Polymorphism In The Metallothionein 2A Gene With Coronary Heart Disease

Objective To investigate the association between theï¹£838G/C polymorphism in the metallothionein 2A(MT2A) gene and coronary heart disease(CHD) in Chinese Han population of Jiangsu, and the effect of different genotype on the severity of coronary stenosis.Methods The genotypes ofï¹£838G/C polymorphism in the MT2A gene were detected by single-labeled probe technique in 287 CHD patients and 226 healthy controls. Blood lipids, blood glucose and body mass index were determined among two groups. The severity of coronary stenosis in CHD patients were evaluated by Gensini,s coronary score.Results The highest frequency of MT2Aï¹£838G/C genetic variation was GG genotype, the next was GC genotype and the lowest was CC genotype in Chinese Han population of Jiangsu. There was significant difference in frequencies of genotype and allele inï¹£838G/C polymorphism between CHD and control group respectively(P<0.05). The frequency of theï¹£838C allele in the patients with CHD group was significantly higher than that in the control group (31.4% vs 24.6%,P=0.016). The relative risk of suffering from CHD with C allele carriers(GC+CC genotype) was 1.562 times higher than those with GG genotype(OR=1.562,95%CI:1.099-2.218,P=0.013). Logistic regression analysis found that carrying C allele was an independent risk factor for CHD(P<0.05). Compared with non- C allele carriers, C allele carriers had significantly higher Gensini,s coronary score in the CHD group. (P<0.05).Conclusions The MT2Aï¹£838G/C polymorphism is associated with CHD in Chinese Han population of Jiangsu. C allele may be one of the genetic susceptible gene for CHD and may influent on the severity of coronary stenosis.