A Clinical Analysis Of Cervical Disease During Gestational Period

Objective:Retrospective analysis of pregnancy by cervical lesions in patients with clinical data, relevant laboratory examinations and treatment measures and pregnancy outcome of pregnant women routinely for screening of cervical disease, the necessity and safety of simultaneous analysis of cervical lesions during pregnancy and effective prevention, clinical and pathological characteristics, treatment characteristics and prognosis of the situation and to explore the clinical treatment of cervical cancer in pregnancy strategy.Methods:Collected in January 2008-February 2010 in Dalian Medical University Second Affiliated Hospital, a hospital and conventional cervical cytology during pregnancy for women in 212 cases of clinical data, select the same period 500 cases of gynecological patients as a control group. Retrospective analysis of patients with cervical lesions during pregnancy liquid-based cytology results, a positive diagnosis of elderly persons with human papillomavirus test and colposcopy cervical biopsy, the pathological examination, analysis of patients with cervical lesions during pregnancy clinical and pathological features and diagnosis features and to further explore the rational cervical lesions during pregnancy clinic program.Results:1.Cervical cytology for cervical infection prompted the overall incidence of lesions and the incidence of cervical epithelial cells in lesions pregnant group and non-pregnant women's team was no significant difference compared; 2.Histopathology and cytology test results were in line with the rate of ASCUS45.590%, LSIL76.92%, HSIL85.71%, SCC 100%, shows that the higher the level lesions, TBS cellular pathology and histo- pathological diagnosis of the more consistent; Pathological histology and cytology consistent with the overall rate of 55.32%;3.High-risk HPV-positive increased with the severity of pathological lesions increase; clinical observation of 212 cases of pregnant women, the late stages of pregnancy, high-risk HPV infection rates are highest, followed by second trimester of pregnancy, pregnancy stages of HPV infection rate difference was significant; 4.Pregnancy CINⅡ-Ⅲconservative treatment, post-natal follow-up, diagnosis and pregnancy test results compare the disease progression-free; 5.5 cases of cervical cancer during pregnancy,1 case for the merger in late pregnancy CIS, OK cesarean hysterectomy and 3 cases of early pregnancy,1 case of second trimester, are taking radical surgical treatment, were followed up after no recurrence and metastasis; 6.Pregnancy-line TCT, high-risk HPV test and cervical biopsy under colposcopy had no effect on pregnancy outcome。Conclusion:Pregnant women the incidence of cervical lesions and non-pregnant women similar; antenatal screening should be carried out contribute to the timely detection of cervical disease, cervical lesions, TCT screening and cervical biopsy under colposcopy for pregnant women is safe and feasible and, if necessary, and for cervical cancer and precancerous lesions of early diagnosis has an important value; the same time decided to treat pregnant women with cervical intraepithelial neoplasia lesions of the first elements of staging, followed by pregnancy, age, pregnancy weeks, pregnancy number and availability of child-bearing requirements. Comprehensive consideration of all factors before deciding on personalized treatment programs.